Polyethylene Glycol + Propylene Glycol

Generic Details

Generic Name

Polyethylene-Glycol-Propylene-Glycol

Other Names

  • PEG-PPG

Drug Class

  • Osmotic Laxative

Chemical Formula

Variable

Molecular Weight

Variable

Mechanism of Action

  • Exerts osmotic effect in the GI tract, drawing water into the lumen, resulting in laxative effect

Indications

  • Constipation
  • Bowel preparation for colonoscopy or surgery

Common Dosage Forms

  • Oral solution
  • Powder for reconstitution

Typical Dosage

  • 17 grams (1 capful) once daily for constipation

Pediatric Dosage

  • Consult healthcare provider for appropriate dosage

Geriatric Dosage

  • May require lower doses due to increased risk of dehydration and electrolyte imbalances

Side Effects

  • Diarrhea
  • Abdominal cramps
  • Nausea
  • Flatulence
  • Electrolyte imbalances

Contraindications

  • Intestinal obstruction
  • Severe inflammatory conditions of the GI tract

Pregnancy Category

  • C - consult healthcare provider

Lactation Safety

  • Compatible with breastfeeding

Drug Interactions

  • May interact with other laxatives or medications affecting water and electrolyte balance

Overdose Symptoms

  • Severe diarrhea
  • Dehydration
  • Electrolyte imbalances

Antidote for Overdose

  • Discontinue use and provide supportive care

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Minimal systemic absorption
  • Distribution: Not applicable
  • Metabolism: Not metabolized in the body
  • Excretion: Excreted unchanged in the feces

Precautions

  • Use with caution in patients with renal impairment

Warnings

  • Ensure adequate fluid intake while using this medication

Others

  • May take 1-3 days for full effect to be realized