Povidone Iodine

Generic Name

Povidone-Iodine

Other Names

• PVP-I
• Betadine

Drug Class

• Antiseptic
• Topical Disinfectant

Chemical Formula

C6H9I2NO

Molecular Weight

364.94 g/mol

Mechanism of Action

• Antiseptic properties due to the release of free iodine which disrupts the cell wall of microorganisms

Indications

• Topical treatment of minor wounds
• Preoperative skin preparation
• Antisepsis in burn wounds
• Oral hygiene as mouthwash or gargle

Common Dosage Forms

• Topical solution
• Ointment
• Swab
• Oral rinse

Typical Dosage

• Apply to the affected area 1 to 3 times daily as directed

Pediatric Dosage

• Consult healthcare provider for appropriate use in children

Geriatric Dosage

• No specific dosage adjustments recommended

Side Effects

• Skin irritation
• Allergic reactions
• Staining of skin and clothing

Contraindications

• Hypersensitivity to iodine or povidone
• Thyroid disorders

Pregnancy Category

• Safe for use during pregnancy when used as directed

Lactation Safety

• Considered safe during lactation when used as directed and not on large areas of skin

Drug Interactions

• No significant drug interactions reported with topical use

Overdose Symptoms

• Unlikely with topical use

Antidote for Overdose

• Not applicable for topical use

Storage Conditions

• Store at room temperature away from moisture and heat

Pharmacokinetics

• Absorption: Minimal systemic absorption through intact skin
• Distribution: Not well studied
• Metabolism: Not metabolized significantly
• Excretion: Excreted unchanged in feces and urine

Precautions

• Avoid contact with eyes, ears, and mucous membranes
• Not for use on large areas of deep puncture wounds

Warnings

• For external use only
• Not for long-term use or on large areas of skin
• Discontinue use if irritation or sensitization occurs

Others

• Do not use concurrently with other antiseptics or soaps as they may inactivate povidone-iodine