Prasugrel Hydrochloride
Generic Details
Generic Name
Prasugrel Hydrochloride
Other Names
- Effient
Drug Class
- Antiplatelet agent
Chemical Formula
C20H20FNO3S
Molecular Weight
373.44 g/mol
Mechanism of Action
- Inhibits platelet activation and aggregation by irreversibly blocking the P2Y12 adenosine diphosphate receptor on platelets
Indications
- Prevention of blood clots in patients with acute coronary syndrome, including those undergoing angioplasty and stenting
Common Dosage Forms
- Tablet
Typical Dosage
- Loading dose of 60 mg, followed by a maintenance dose of 10 mg once daily
Pediatric Dosage
Geriatric Dosage
Side Effects
- Bleeding, including life-threatening and fatal bleeding, hypersensitivity reactions, chest pain, headache, dizziness, and thrombotic thrombocytopenic purpura
Contraindications
- Active pathological bleeding, history of transient ischemic attack or stroke, urgent need for surgery
Pregnancy Category
- B
Lactation Safety
- Unknown if excreted in breast milk, use caution
Drug Interactions
- Strong CYP2C19 inhibitors may increase the risk of bleeding
Overdose Symptoms
- Increased risk of bleeding
Antidote for Overdose
- Platelet transfusion, activated charcoal if ingestion was recent
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Highly bound to plasma proteins
- Metabolism: Extensively metabolized in the liver via CYP3A4 and CYP2B6 enzymes
- Excretion: Primarily excreted in the urine
Precautions
- Use with caution in patients at risk for bleeding, history of stroke or TIA, and renal impairment
Warnings
- Increased risk of bleeding, do not discontinue abruptly
Others
- Avoid use in patients with a history of stroke as they have an increased risk of intracranial hemorrhage