Prednisolone
Generic Details
Generic Name
Prednisolone
Other Names
- Orapred
- Pediapred
- Prelone
Drug Class
- Corticosteroid
Chemical Formula
C21H28O5
Molecular Weight
360.45 g/mol
Mechanism of Action
- Prednisolone interacts with specific intracellular receptors to induce anti-inflammatory and immunosuppressive effects.
Indications
- Allergic conditions
- Autoimmune diseases
- Skin conditions
- Respiratory disorders
- Rheumatic disorders
Common Dosage Forms
- Tablet
- Oral solution
- Oral disintegrating tablet
- Injection
- Ointment
- Eye drops
Typical Dosage
- 5-60 mg per day, depending on the condition being treated
Pediatric Dosage
- Based on weight and condition, typically lower than adult dosage
Geriatric Dosage
- May require lower doses due to decreased metabolism
Side Effects
- Insomnia
- Nausea
- Weight gain
- Mood changes
- Increased appetite
- Delayed wound healing
- Fluid retention
Contraindications
- Hypersensitivity to prednisolone
- Systemic fungal infections
Pregnancy Category
- Category C - Consult healthcare provider before use during pregnancy
Lactation Safety
- Caution advised, excreted in breast milk
Drug Interactions
- NSAIDs
- Anticoagulants
- Diuretics
Overdose Symptoms
- Severe headache
- Blurred vision
- Confusion
- Seizures
Antidote for Overdose
- No specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Crosses the placenta and is excreted in breast milk
- Metabolism: Metabolized in the liver
- Excretion: Primarily excreted in urine
Precautions
- Monitor blood glucose levels in diabetic patients
- Use caution in patients with hypertension or renal impairment
Warnings
- Abrupt discontinuation can lead to adrenal insufficiency
- Long-term use can suppress the immune system
Others
- Prednisolone should be taken with food to reduce stomach upset