Prochlorperazine Maleate
Generic Details
Generic Name
Prochlorperazine Maleate
Other Names
- Compazine
- Buccastem
- Stemetil
Drug Class
- Antipsychotic
- Antiemetic
- Phenothiazine
Chemical Formula
C20H24ClN3O4
Molecular Weight
375.87 g/mol
Mechanism of Action
- Blocks dopamine receptors in the brain
Indications
- Nausea and vomiting
- Psychotic disorders
- Anxiety
Common Dosage Forms
- Tablet
- Syrup
- Injection
Typical Dosage
- 5-10 mg taken orally 2-3 times a day
Pediatric Dosage
- Consult pediatrician for appropriate dosage
Geriatric Dosage
- Lower doses may be required due to decreased metabolism
Side Effects
- Drowsiness
- Dizziness
- Dry mouth
- Constipation
- Blurred vision
Contraindications
- Coma
- Severe CNS depression
- Reye syndrome
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Not recommended, excreted in breast milk
Drug Interactions
- Alcohol
- CNS depressants
- Anticholinergic drugs
Overdose Symptoms
- Seizures
- Cardiac arrhythmias
- Coma
Antidote for Overdose
- Activated charcoal
- Symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from GI tract
- Distribution: Crosses blood-brain barrier, widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Use with caution in elderly
- Monitor for extrapyramidal symptoms
Warnings
- May cause extrapyramidal symptoms
- Avoid sudden discontinuation
Others
- May cause photosensitivity, avoid prolonged exposure to sunlight