Propantheline Bromide
Generic Details
Generic Name
Propantheline-Bromide
Other Names
- Pro-Banthine
Drug Class
- Anticholinergic
Chemical Formula
C23H30BrNO3
Molecular Weight
437.39 g/mol
Mechanism of Action
- Blocks the action of acetylcholine at parasympathetic sites in smooth muscle, secretory glands, and the central nervous system.
Indications
- Treatment of peptic ulcers
- Irritable bowel syndrome
- Bladder control problems
Common Dosage Forms
- Tablet
- Oral solution
Typical Dosage
- 15-30 mg 3-4 times daily
Pediatric Dosage
- Not recommended for pediatric use
Geriatric Dosage
- Dose adjustments may be required for elderly patients
Side Effects
- Dry mouth
- Blurred vision
- Constipation
- Urinary retention
- Confusion
Contraindications
- Glaucoma
- Obstructive uropathy
- Myasthenia gravis
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Caution advised; excretion into breast milk is unknown
Drug Interactions
- May potentiate the effects of other anticholinergic drugs
- May interact with certain antibiotics and antifungal medications
Overdose Symptoms
- Severe dry mouth
- Blurred vision
- Flushed skin
- Fever
Antidote for Overdose
- No specific antidote, treatment is supportive
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Widely distributed in the body
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the urine
Precautions
- Use with caution in patients with a history of urinary retention
- Monitor for worsening of glaucoma symptoms
Warnings
- May cause drowsiness or blurred vision, caution advised when driving or operating machinery
Others
- Avoid alcohol consumption while taking this medication