Atracurium Besilate
Generic Details
Generic Name
Atracurium Besilate
Other Names
- Atracurium
Drug Class
- Nondepolarizing neuromuscular blocking agent
Chemical Formula
C53H72N2O12.2C6H6O4S
Molecular Weight
1242.57 g/mol
Mechanism of Action
- Competitive antagonist at the neuromuscular junction
Indications
- Muscle relaxation during surgery or mechanical ventilation
Common Dosage Forms
- Injection
Typical Dosage
- 0.5 mg/kg to 0.6 mg/kg, repeated as needed
Pediatric Dosage
- Dose adjustments based on weight and age
Geriatric Dosage
- Lower initial dose may be required in the elderly
Side Effects
- Hypotension
- Bronchospasm
- Bradycardia
- Hypersensitivity reactions
Contraindications
- Known hypersensitivity to atracurium or any components
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Not recommended, use with caution
Drug Interactions
- Lithium
- Tetracyclines
- Procainamide
- Calcium channel blockers
Overdose Symptoms
- Prolonged neuromuscular blockade
- Respiratory depression
Antidote for Overdose
- Cholinesterase inhibitors such as neostigmine or edrophonium
Storage Conditions
- Store at controlled room temperature (20°C to 25°C)
Pharmacokinetics
- Absorption: Rapidly hydrolyzed in plasma
- Distribution: Distributed throughout the body
- Metabolism: Metabolized by ester hydrolysis
- Excretion: Excreted mainly through the kidneys
Precautions
- Caution in patients with history of hypersensitivity reactions
Warnings
- Should only be administered by healthcare professionals experienced in managing neuromuscular blockade
Others
- Requires adequate ventilation and close monitoring during use