Pyrantel Pamoate
Generic Details
Generic Name
Pyrantel Pamoate
Other Names
- Pyrantel Embonate
- Pyrantel
Drug Class
- Anthelmintic
Chemical Formula
C11H14N2S
Molecular Weight
234.31 g/mol
Mechanism of Action
- Pyrantel Pamoate acts as a depolarizing neuromuscular blocking agent, causing paralysis of the helminths
Indications
- Treatment of pinworm infections
- Treatment of roundworm infections
- Treatment of hookworm infections
Common Dosage Forms
- Tablet
- Chewable tablet
- Suspension
Typical Dosage
- 11 mg/kg as a single dose
- Repeat in 2 weeks for certain infections
Pediatric Dosage
- Consult healthcare provider for appropriate dosage based on weight
Geriatric Dosage
- Dose adjustment may be needed based on renal function
Side Effects
- Nausea
- Vomiting
- Abdominal pain
- Diarrhea
- Dizziness
Contraindications
- Hypersensitivity to pyrantel pamoate
- Severe liver disease
Pregnancy Category
- C - Risk cannot be ruled out
Lactation Safety
- Caution advised, excretion in breast milk unknown
Drug Interactions
- No clinically significant interactions reported
Overdose Symptoms
- Nausea
- Vomiting
- Abdominal cramps
Antidote for Overdose
- Symptomatic treatment, monitoring
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed from the gastrointestinal tract
- Distribution: Primarily localizes in the gastrointestinal tract
- Metabolism: Primarily hepatic
- Excretion: Mainly via urine
Precautions
- Caution in patients with liver disease
- Caution in pregnancy and lactation
Warnings
- Avoid in patients with known hypersensitivity to pyrantel pamoate
Others
- May be administered with or without food