Pyridoxine Hydrochloride

Generic Details

Generic Name

Pyridoxine Hydrochloride

Other Names

  • Vitamin B6 Hydrochloride

Drug Class

  • Vitamin

Chemical Formula

C8H11NO3.HCl

Molecular Weight

205.64 g/mol

Mechanism of Action

  • Pyridoxine hydrochloride is the hydrochloride salt form of pyridoxine, a form of vitamin B6. It acts as a coenzyme in the metabolism of carbohydrates, proteins, and fats.

Indications

  • Treatment of vitamin B6 deficiency
  • Adjunct therapy in the treatment of certain types of anemia
  • Pregnancy-induced nausea and vomiting
  • Prevention and treatment of peripheral neuropathy

Common Dosage Forms

  • Tablet
  • Capsule
  • Injection

Typical Dosage

  • 25-100 mg oral tablet daily for adults

Pediatric Dosage

  • Varies based on age and weight. It is recommended to follow pediatrician's advice.

Geriatric Dosage

  • Dosage adjustments may be needed based on renal function and individual requirements.

Side Effects

  • Nausea
  • Vomiting
  • Headache
  • Numbness or tingling

Contraindications

  • Hypersensitivity to vitamin B6 or any component of the formulation

Pregnancy Category

  • Generally considered safe for use during pregnancy when taken at recommended doses

Lactation Safety

  • Considered safe when used in recommended doses during lactation

Drug Interactions

  • Levodopa
  • Phenytoin
  • Cycloserine
  • Doxylamine
  • Hydralazine

Overdose Symptoms

  • Severe numbness or tingling
  • Sensory neuropathy
  • Ataxia
  • Impairment of position sense

Antidote for Overdose

  • No specific antidote, treatment is supportive and symptomatic

Storage Conditions

  • Store in a cool, dry place away from light and moisture

Pharmacokinetics

  • Absorption: Readily absorbed from the gastrointestinal tract
  • Distribution: Distributed widely to body tissues
  • Metabolism: Metabolized in the liver to active forms of vitamin B6
  • Excretion: Primarily excreted in the urine

Precautions

  • Monitor for signs of vitamin B6 toxicity in long-term use
  • Use with caution in patients with kidney disease

Warnings

  • Do not exceed recommended dosage
  • Consult a healthcare professional before starting pyridoxine supplementation

Others