Quetiapine Fumarate
Generic Details
Generic Name
Quetiapine Fumarate
Other Names
- Seroquel
Drug Class
- Atypical Antipsychotic
Chemical Formula
C21H25N3O2S
Molecular Weight
383.51 g/mol
Mechanism of Action
- Antagonist at serotonin and dopamine receptors
Indications
- Schizophrenia
- Bipolar disorder
- Major depressive disorder
- Generalized anxiety disorder
Common Dosage Forms
- Tablet
- Extended-release tablet
Typical Dosage
- Schizophrenia: 150-750 mg/day
- Bipolar disorder: 400-800 mg/day
- Depressive disorder: 150-300 mg/day
Pediatric Dosage
- Not established
Geriatric Dosage
- Initiate at lower doses due to increased sensitivity
Side Effects
- Drowsiness
- Weight gain
- Dry mouth
- Dizziness
- Constipation
Contraindications
- Hypersensitivity to quetiapine
- Recent myocardial infarction
- Uncontrolled epilepsy
Pregnancy Category
- C
Lactation Safety
- May pass into breast milk
Drug Interactions
- CNS depressants
- Antihypertensives
- Antidepressants
Overdose Symptoms
- Extreme drowsiness
- Rapid heart rate
- Seizures
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature away from light and moisture
Pharmacokinetics
- Absorption: Rapid and well-absorbed
- Distribution: Highly distributed in tissues
- Metabolism: Extensively hepatic via CYP3A4
- Excretion: Mainly in urine and feces
Precautions
- Caution in elderly patients with dementia-related psychosis
- Risk of suicidal thoughts in young adults
Warnings
- Risk of agranulocytosis
- Increased mortality in elderly patients with dementia
Others
- May cause orthostatic hypotension