Rabeprazole Sodium
Generic Details
Generic Name
Rabeprazole Sodium
Other Names
- Rabeprazole
Drug Class
- Proton Pump Inhibitor
Chemical Formula
C18H20N3NaO3S
Molecular Weight
381.42 g/mol
Mechanism of Action
- Blocks the proton pump in gastric parietal cells, reducing gastric acid secretion
Indications
- Gastroesophageal reflux disease (GERD)
- Peptic ulcer disease
- Zollinger-Ellison syndrome
- Erosive esophagitis
Common Dosage Forms
- Tablet
- Delayed-release capsule
Typical Dosage
- 20 mg once daily before a meal
Pediatric Dosage
- Safety and efficacy not established in children
Geriatric Dosage
- No dosage adjustment necessary in the elderly
Side Effects
- Headache
- Nausea
- Abdominal pain
- Diarrhea
- Constipation
Contraindications
- Hypersensitivity to rabeprazole
- Co-administration with rilpivirine-containing products
Pregnancy Category
- Category B
Lactation Safety
- Probably safe to use during breastfeeding
Drug Interactions
- Warfarin
- Ketoconazole
- Digoxin
Overdose Symptoms
- Confusion
- Drowsiness
- Blurred vision
Antidote for Overdose
- No specific antidote; provide supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Rapidly absorbed from the gastrointestinal tract
- Distribution: Extensively bound to plasma proteins
- Metabolism: Primarily metabolized in the liver
- Excretion: Excreted in urine and feces
Precautions
- Monitor magnesium levels in long-term use
- Avoid abrupt discontinuation
Warnings
- Increased risk of Clostridium difficile-associated diarrhea
- Potential risk of osteoporosis-related fractures