Racecadotril

Generic Details

Generic Name

Racecadotril

Other Names

  • Acetorphan

Drug Class

  • Antidiarrheal agent

Chemical Formula

C21H23NO4

Molecular Weight

357.41 g/mol

Mechanism of Action

  • Inhibition of enkephalinase enzyme leading to increased levels of endogenous enkephalins in the gut, reducing fluid and electrolyte secretion in the intestines

Indications

  • Acute diarrhea in adults and children

Common Dosage Forms

  • Oral capsules
  • Oral solution

Typical Dosage

  • 100 mg three times a day

Pediatric Dosage

  • Infants and children: 1.5 mg/kg three times a day

Geriatric Dosage

  • No adjustment needed in the elderly

Side Effects

  • Abdominal pain
  • Nausea
  • Vomiting
  • Flatulence

Contraindications

  • Hypersensitivity to racecadotril or any components of the formulation

Pregnancy Category

  • Not classified

Lactation Safety

  • Limited data available; use with caution

Drug Interactions

  • No clinically significant interactions reported

Overdose Symptoms

  • No specific symptoms reported

Antidote for Overdose

  • No specific antidote; supportive care

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Well-absorbed after oral administration
  • Distribution: High distribution in the gastrointestinal tract
  • Metabolism: Metabolized mainly in the liver
  • Excretion: Primarily excreted in the urine

Precautions

  • Monitor electrolyte levels especially in patients with renal impairment

Warnings

  • Not recommended for the treatment of bloody diarrhea or diarrhea caused by infections

Others

  • May take with or without food