Ranitidine Hydrochloride

Generic Details

Generic Name

Ranitidine Hydrochloride

Other Names

  • Zantac
  • Zantac 360

Drug Class

  • H2-receptor antagonist

Chemical Formula

C13H23N4O3S.HCl

Molecular Weight

350.87 g/mol

Mechanism of Action

  • Blocks histamine H2 receptors, reducing gastric acid secretion

Indications

  • Gastric and duodenal ulcers
  • Gastroesophageal reflux disease (GERD)
  • Zollinger-Ellison Syndrome
  • Heartburn
  • Indigestion

Common Dosage Forms

  • Tablet
  • Capsule
  • Injection

Typical Dosage

  • 150 mg twice daily or 300 mg at bedtime

Pediatric Dosage

  • Consult a healthcare provider for appropriate dosing in children

Geriatric Dosage

  • Dose adjustment may be needed; consult a healthcare provider

Side Effects

  • Headache
  • Dizziness
  • Constipation
  • Diarrhea
  • Nausea

Contraindications

  • Hypersensitivity to ranitidine or other H2-receptor antagonists

Pregnancy Category

  • Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus but no adequate studies in pregnant women

Lactation Safety

  • Compatible with breastfeeding; considered safe to use

Drug Interactions

  • May interact with antacids, ketoconazole, atazanavir, delavirdine, etc.

Overdose Symptoms

  • Bradycardia
  • Hypotension
  • Confusion

Antidote for Overdose

  • Symptomatic and supportive treatment; no specific antidote

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration
  • Distribution: Widely distributed in the body
  • Metabolism: Partially metabolized by the liver
  • Excretion: Mainly excreted in the urine

Precautions

  • Caution in patients with renal or hepatic impairment

Warnings

  • May increase the risk of pneumonia, especially in the elderly

Others

  • It is important to seek medical advice before taking ranitidine hydrochloride for prolonged periods.