Intravenous fat emulsion
Generic Details
Generic Name
Intravenous Fat Emulsion
Other Names
- Intralipid
- Liposyn
- Lipidem
Drug Class
- Parenteral Nutrition
Chemical Formula
Not Applicable
Molecular Weight
Not Applicable
Mechanism of Action
- Provides essential fatty acids and a source of non-protein calories for patients who cannot eat by mouth or by tube feeding.
Indications
- Treatment of essential fatty acid deficiency
- Caloric support in critically ill patients
- Parenteral nutrition in patients with malabsorption
Common Dosage Forms
- Injection
Typical Dosage
- The dosage is individualized based on the patient's nutritional needs and medical condition.
Pediatric Dosage
- Specific dosing guidelines should be followed for pediatric patients.
Geriatric Dosage
- Specific dosing guidelines should be followed for geriatric patients.
Side Effects
- Allergic reactions
- Hypertriglyceridemia
- Hyperlipidemia
- Sepsis
- Thrombosis
Contraindications
- Known allergy to egg or soybean proteins
- Severe hyperlipidemia
- Severe liver disease
Pregnancy Category
- Not classified. Use with caution during pregnancy.
Lactation Safety
- Limited data available. Caution advised.
Drug Interactions
- Interacts with warfarin, propofol, insulin, and certain antibiotics. Close monitoring is required.
Overdose Symptoms
- Excessive lipid levels in the blood
Antidote for Overdose
- Discontinue the infusion and provide supportive care.
Storage Conditions
- Store at room temperature. Protect from light.
Pharmacokinetics
- Absorption: N/A - Administered intravenously
- Distribution: Incorporated into chylomicrons and transported in the blood
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the bile
Precautions
- Monitor triglyceride levels, liver function, and signs of infection during therapy.
Warnings
- Risk of fat overload syndrome in patients with impaired metabolism of lipids.