Repaglinide

Generic Details

Generic Name

Repaglinide

Other Names

  • Prandin
  • NovoNorm

Drug Class

  • Meglitinide antidiabetic

Chemical Formula

C27H36N2O4

Molecular Weight

452.59 g/mol

Mechanism of Action

  • Stimulates insulin release from pancreatic beta cells by closing ATP-sensitive potassium channels

Indications

  • Type 2 diabetes mellitus

Common Dosage Forms

  • Oral tablets

Typical Dosage

  • 0.5-4 mg before each main meal

Pediatric Dosage

  • Not established

Geriatric Dosage

  • Dose adjustments may be needed based on renal function

Side Effects

  • Hypoglycemia
  • Headache
  • Upper respiratory tract infection
  • Nausea
  • Diarrhea

Contraindications

  • Type 1 diabetes mellitus
  • Diabetic ketoacidosis
  • Severe liver dysfunction

Pregnancy Category

  • C

Lactation Safety

  • Use with caution

Drug Interactions

  • Gemfibrozil
  • Erythromycin
  • Clarithromycin
  • Azole antifungals

Overdose Symptoms

  • Hypoglycemia

Antidote for Overdose

  • Glucose or glucagon IV

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly absorbed from the gastrointestinal tract
  • Distribution: Highly protein-bound
  • Metabolism: Primarily metabolized by the liver
  • Excretion: Mainly excreted in bile

Precautions

  • Renal impairment
  • Hepatic impairment
  • Hypoglycemia risk

Warnings

  • Hypoglycemia risk increases when taken with skipped meals or at irregular meal times

Others

  • Requires mealtime dosing to ensure effectiveness