Risperidone (Oral)
Generic Details
Generic Name
Risperidone Oral
Other Names
- Risperdal
Drug Class
- Atypical Antipsychotic
Chemical Formula
C23H27FN4O2
Molecular Weight
410.49 g/mol
Mechanism of Action
- Antagonist at serotonin 5-HT2 receptors
- Antagonist at dopamine D2 receptors
Indications
- Schizophrenia
- Bipolar Disorder
- Irritability in Autism
Common Dosage Forms
- Tablet
- Oral Solution
Typical Dosage
- 2-4 mg once or twice daily for schizophrenia
- 0.5-3 mg once daily for bipolar disorder
Pediatric Dosage
- Dosage based on weight and age, consult a pediatrician
Geriatric Dosage
- Low initial dose, titrate slowly
Side Effects
- Weight gain
- Sedation
- Hyperprolactinemia
- Extrapyramidal symptoms
Contraindications
- Known hypersensitivity to risperidone
- Patients with dementia-related psychosis
Pregnancy Category
- Category C - Risk cannot be ruled out
Lactation Safety
- Caution advised, excretion in breast milk reported
Drug Interactions
- Strong CYP2D6 inhibitors
Overdose Symptoms
- Increased heart rate
- Agitation
- Sedation
- Seizures
Antidote for Overdose
- No specific antidote, symptomatic treatment
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Extensively distributed in the body
- Metabolism: Primarily hepatic via CYP2D6 and CYP3A4 enzymes
- Excretion: Mainly via urine (70%) and feces (14%)
Precautions
- Monitor for neuroleptic malignant syndrome
- Cardiac monitoring in patients at risk for QT prolongation
Warnings
- Increased risk of stroke in elderly patients with dementia-related psychosis
Others
- May cause orthostatic hypotension, monitor blood pressure