Rosuvastatin Calcium
Generic Details
Generic Name
Rosuvastatin Calcium
Other Names
- Crestor
Drug Class
- HMG-CoA reductase inhibitors
Chemical Formula
C44H54CaF2N6O12S2
Molecular Weight
1001.14 g/mol
Mechanism of Action
- Inhibition of HMG-CoA reductase enzyme
Indications
- Hyperlipidemia
- Mixed dyslipidemia
- Hypertriglyceridemia
Common Dosage Forms
- Tablet
Typical Dosage
- 5-40 mg once daily, with or without food
Pediatric Dosage
- Not established
Geriatric Dosage
- Usually initiated at a lower dose due to increased risk of adverse effects
Side Effects
- Muscle pain or weakness
- Liver enzyme abnormalities
- Headache
- Nausea
- Constipation
Contraindications
- Active liver disease
- Pregnancy
- Lactation
Pregnancy Category
- Category X - Contraindicated
Lactation Safety
- Risk of adverse effects on the infant, discontinue breastfeeding or the drug
Drug Interactions
- Avoid concomitant use with gemfibrozil, cyclosporine, protease inhibitors
Overdose Symptoms
- Myopathy
- Liver dysfunction
Antidote for Overdose
- Supportive care and monitoring
Storage Conditions
- Store at room temperature (20-25°C)
Pharmacokinetics
- Absorption: Rapidly absorbed after oral administration
- Distribution: Highly distributed in the liver
- Metabolism: Primarily metabolized in the liver via CYP2C9
- Excretion: Excreted in feces (90%) and urine (10%)
Precautions
- Routine monitoring of liver function tests
- Avoid excessive alcohol consumption
Warnings
- Increased risk of myopathy and rhabdomyolysis
- Routine monitoring of liver function is recommended
Others
- Rosuvastatin is considered a high-intensity statin therapy