Roxithromycin
Generic Details
Generic Name
Roxithromycin
Other Names
- Rulide
- Surlid
Drug Class
- Macrolide Antibiotic
Chemical Formula
C41H76N2O15
Molecular Weight
837.07 g/mol
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome
Indications
- Respiratory tract infections
- Skin and soft tissue infections
- Acute pharyngitis
- Tonsillitis
- Sinusitis
Common Dosage Forms
- Tablet
- Oral Suspension
Typical Dosage
- 150 mg to 300 mg twice daily before meals
Pediatric Dosage
- Children: 5-8 mg/kg/day in two divided doses
Geriatric Dosage
- Adjust dose based on renal function
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Rash
- Headache
Contraindications
- Hypersensitivity to macrolide antibiotics
Pregnancy Category
- Category B
Lactation Safety
- Safe, excreted in breast milk in small amounts
Drug Interactions
- Warfarin
- Theophylline
- Ciclosporin
Overdose Symptoms
- Nausea
- Vomiting
- Dehydration
Antidote for Overdose
- Supportive care
Storage Conditions
- Store at room temperature below 25°C
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Widely distributed in tissues
- Metabolism: Metabolized in the liver
- Excretion: Excreted mainly in the bile and urine
Precautions
- Caution in patients with hepatic impairment
- Caution in patients with renal impairment
Warnings
- May cause QT prolongation
- Prolonged use may lead to bacterial resistance
Others
- Complete the full course of antibiotics as prescribed