Rupatadine Fumarate
Generic Details
Generic Name
Rupatadine Fumarate
Other Names
- Rupatadine
- Rupatadine Dihydrochloride
Drug Class
- Second-generation antihistamine
- Mast cell stabilizer
Chemical Formula
C26H26Cl2N2O4
Molecular Weight
502.402 g/mol
Mechanism of Action
- Acts as a selective antagonist of histamine H1 receptors and exhibits anti-inflammatory and antiallergic properties.
Indications
- Allergic rhinitis
- Conjunctivitis
- Urticaria
- Atopic dermatitis
Common Dosage Forms
- Tablet
- Oral solution
Typical Dosage
- 10 mg once daily
Pediatric Dosage
- Children 6-11 years: 5 mg once daily
Geriatric Dosage
- No dosage adjustment necessary
Side Effects
- Drowsiness
- Headache
- Dry mouth
- Fatigue
Contraindications
- Hypersensitivity to rupatadine
- Severe hepatic impairment
Pregnancy Category
- Category C - Safety has not been established
Lactation Safety
- Use with caution in breastfeeding women
Drug Interactions
- Avoid concurrent use with strong CYP3A4 inhibitors
Overdose Symptoms
- Sedation
- Tachycardia
- Agitation
Antidote for Overdose
- No specific antidote, manage symptoms supportively
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed after oral administration
- Distribution: Highly protein-bound
- Metabolism: Mainly hepatic via CYP3A4 and CYP2D6
- Excretion: Primarily in feces
Precautions
- Use with caution in patients with severe renal impairment
Warnings
- May cause drowsiness, avoid driving or operating heavy machinery
Others
- Not recommended for use in children under 6 years old