Salmon Calcitonin

Generic Name

Salmon-Calcitonin

Other Names

• Calcitonin-Salmon

Drug Class

• Calcitonin

Chemical Formula

C145H240N44O48S2

Molecular Weight

3430.36 g/mol

Mechanism of Action

• Inhibits bone resorption by acting directly on osteoclasts

Indications

• Osteoporosis
• Paget's disease
• Hypercalcemia

Common Dosage Forms

• Injection
• Nasal spray

Typical Dosage

• 50-100 IU/day administered subcutaneously or intramuscularly

Pediatric Dosage

• Not established

Geriatric Dosage

• May require lower doses due to decreased renal function

Side Effects

• Nausea
• Vomiting
• Flushing
• Injection site reactions

Contraindications

• Hypersensitivity to calcitonin or any component of the formulation

Pregnancy Category

• C - Risk cannot be ruled out

Lactation Safety

• Unknown if excreted in breast milk, use caution

Drug Interactions

• Diuretics may enhance hypocalcemic effect

Overdose Symptoms

• Severe hypocalcemia
• Tingling in extremities

Antidote for Overdose

• Calcium gluconate

Storage Conditions

• Store at 2-8°C (36-46°F), do not freeze

Pharmacokinetics

• Absorption: Well-absorbed after subcutaneous or intramuscular administration
• Distribution: Distributed primarily to bones
• Metabolism: Metabolized in the liver and kidneys
• Excretion: Excreted mainly through the kidneys

Precautions

• Use with caution in patients with known allergy to fish protein

Warnings

• May cause hypersensitivity reactions, discontinue if occurs

Others

• It is a synthetic form of calcitonin, a hormone involved in calcium homeostasis.