Sertraline Hydrochloride
Generic Details
Generic Name
Sertraline Hydrochloride
Other Names
- Zoloft
Drug Class
- Selective Serotonin Reuptake Inhibitor (SSRI)
Chemical Formula
C17H17Cl2N
Molecular Weight
306.2 g/mol
Mechanism of Action
- Inhibits the reuptake of serotonin at the presynaptic membrane, increasing serotonin levels in the synaptic cleft
Indications
- Major depressive disorder
- Obsessive-compulsive disorder
- Panic disorder
- Post-traumatic stress disorder
- Social anxiety disorder
- Premenstrual dysphoric disorder
Common Dosage Forms
- Tablet
- Oral concentrate
Typical Dosage
- 50-200 mg once daily
Pediatric Dosage
- Dosage varies based on weight and condition - consult healthcare provider
Geriatric Dosage
- Lower starting dose of 25 mg once daily
Side Effects
- Nausea
- Diarrhea
- Insomnia
- Sexual dysfunction
- Weight changes
Contraindications
- Hypersensitivity to sertraline
- Concomitant use with MAOIs
Pregnancy Category
- Category C - Discuss risks and benefits with a healthcare provider
Lactation Safety
- Excreted in breast milk - Caution advised
Drug Interactions
- MAOIs
- Warfarin
- NSAIDs
- Triptans
Overdose Symptoms
- Drowsiness
- Nausea
- Vomiting
- Tachycardia
- Tremor
Antidote for Overdose
- There is no specific antidote - Supportive care
Storage Conditions
- Store at room temperature away from moisture and heat
Pharmacokinetics
- Absorption: Well absorbed orally
- Distribution: Widely distributed in the body, crosses the blood-brain barrier
- Metabolism: Primarily hepatic via CYP2B6 and CYP2C19
- Excretion: Mainly in urine
Precautions
- Monitor for worsening of depression or suicidal thoughts especially at the start of therapy
Warnings
- May increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults