Silver Sulfadiazine
Generic Details
Generic Name
Silver Sulfadiazine
Other Names
- Silvadene
- SSD Cream
Drug Class
- Topical antimicrobial
Chemical Formula
C10H9AgN4O2S
Molecular Weight
357.14 g/mol
Mechanism of Action
- Inhibits bacterial growth by interfering with the synthesis of folic acid in bacteria
Indications
- Treatment of burns and preventing infection in burn patients
Common Dosage Forms
- Topical cream
Typical Dosage
- Apply a thin layer to the affected area 1-2 times daily
Pediatric Dosage
- Consult healthcare provider for appropriate dosage
Geriatric Dosage
- Dosage adjustment may be necessary, consult healthcare provider
Side Effects
- Skin irritation
- Burning sensation
- Itching
- Redness
Contraindications
- Hypersensitivity to silver sulfadiazine or sulfonamides
Pregnancy Category
- Category B - Animal reproduction studies have failed to demonstrate a risk to the fetus
Lactation Safety
- Limited data available, consult healthcare provider
Drug Interactions
- No significant drug interactions reported
Overdose Symptoms
- Unlikely with topical application
Antidote for Overdose
- N/A
Storage Conditions
- Store at room temperature
Pharmacokinetics
- Absorption: Limited systemic absorption after topical application
- Distribution: Not well defined
- Metabolism: Not extensively metabolized
- Excretion: Mainly excreted unchanged in the urine
Precautions
- Avoid contact with eyes
- Not for deep puncture wounds or serious burns
Warnings
- Discontinue use and consult healthcare provider if irritation or allergic reaction occurs