Azilsartan Medoxomil

Generic Details

Generic Name

Azilsartan-medoxomil

Other Names

  • Azilsartan

Drug Class

  • Angiotensin II Receptor Blockers (ARBs)

Chemical Formula

C30H24N4O8

Molecular Weight

568.53 g/mol

Mechanism of Action

  • Azilsartan-medoxomil is a prodrug that is hydrolyzed to azilsartan, an angiotensin II receptor antagonist. It works by blocking the binding of angiotensin II to the AT1 receptor in vascular smooth muscle, preventing vasoconstriction.

Indications

  • Hypertension

Common Dosage Forms

  • Tablet

Typical Dosage

  • 40 mg-80 mg once daily

Pediatric Dosage

  • Not established

Geriatric Dosage

  • No dosage adjustment required

Side Effects

  • Dizziness
  • Fatigue
  • Hypotension
  • Hyperkalemia

Contraindications

  • Pregnancy (2nd and 3rd trimesters)
  • Hypersensitivity to azilsartan or other ARBs

Pregnancy Category

  • D

Lactation Safety

  • Lactation is not recommended

Drug Interactions

  • Potassium-sparing diuretics
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Lithium

Overdose Symptoms

  • Hypotension
  • Bradycardia

Antidote for Overdose

  • Symptomatic and supportive treatment

Storage Conditions

  • Store at room temperature away from moisture and heat

Pharmacokinetics

  • Absorption: Rapidly hydrolyzed to azilsartan in the gastrointestinal tract
  • Distribution: Protein binding is high (99%)
  • Metabolism: Undergoes hydrolysis to active metabolite azilsartan
  • Excretion: Primarily excreted in feces (55%) and urine (42%)

Precautions

  • Renal impairment
  • Hepatic impairment
  • Volume-depleted patients
  • Hyperkalemia risk factors

Warnings

  • Fetal toxicity
  • Hypotension
  • Renal impairment

Others

  • It is important to monitor blood pressure regularly and adjust dosage as needed based on individual response.