Bicarbonate Component [HCO3 Hemodialysis Solution]

Generic Name

Bicarbonate hemodialysis solution

Other Names

• Hemodialysis bicarbonate solution
• Dialysis bicarbonate component

Drug Class

• Electrolyte supplement

Chemical Formula

HCO3-

Molecular Weight

61.0168 g/mol

Mechanism of Action

• Helps to correct metabolic acidosis during hemodialysis by buffering excess hydrogen ions in the blood.

Indications

• Treatment of metabolic acidosis in patients undergoing hemodialysis.

Common Dosage Forms

• Solution for hemodialysis use

Typical Dosage

• Administered intravenously during hemodialysis sessions according to the individual patient's needs.

Pediatric Dosage

• Dosage adjustment may be needed based on the weight and condition of the pediatric patient.

Geriatric Dosage

• No specific dosage adjustments are typically required for geriatric patients.

Side Effects

• Rarely, metabolic alkalosis may occur if administered in excess.

Contraindications

• Hypersensitivity to bicarbonate compounds

Pregnancy Category

• Category C: Animal reproduction studies have shown an adverse effect on the fetus, and there are no adequate and well-controlled studies in humans.

Lactation Safety

• Caution advised as it is not known whether the drug is excreted in human milk.

Drug Interactions

• No significant drug interactions reported.

Overdose Symptoms

• Metabolic alkalosis, hypokalemia

Antidote for Overdose

• Administration of potassium chloride as needed.

Storage Conditions

• Store at controlled room temperature away from light and moisture.

Pharmacokinetics

• Absorption: Not applicable as it is administered intravenously.
• Distribution: Distributed into the extracellular fluid compartment.
• Metabolism: Metabolized to carbon dioxide and water in the body.
• Excretion: Excreted primarily via the lungs as carbon dioxide and in urine as bicarbonate ions.

Precautions

• Monitor electrolyte levels during treatment, especially potassium.

Warnings

• Ensure proper dosing to avoid metabolic alkalosis.