Mavyret (glecaprevir/pibrentasvir) is a prescription medication specifically designed to treat chronic hepatitis C. While Mavyret is effective, it may lead to a range of side effects, some of which can be mild, while others may be more serious.

This medication is approved for use in adults and children aged 3 years and older to manage:

• Chronic hepatitis C virus (HCV) genotypes 1 through 6, either with no liver scarring or with compensated cirrhosis.
• Chronic HCV genotype 1 in patients previously treated with other therapies that were unsuccessful.

Composed of glecaprevir and pibrentasvir, Mavyret comes in tablet and pellet forms for convenient oral administration. Continue reading to explore the potential common, mild, and severe side effects associated with Mavyret.

Like any medication, Mavyret can produce side effects in some individuals. Commonly reported side effects include:

• Headaches
• Fatigue or lack of energy
• Nausea
• Diarrhea

Further details on Mavyret’s side effects will be covered in subsequent sections.

Many individuals taking Mavyret will experience mild side effects, which are usually manageable and often subside with time. Common mild side effects include:

• Headaches
• Nausea
• Itching*
• Fatigue*
• Elevated bilirubin levels*

Other mild side effects may occur, and detailed information can be found in the prescribing information.

Note: The FDA monitors side effects post-approval. It is encouraged to report any side effects experienced while taking Mavyret through MedWatch. Some mild side effects may reflect symptoms related to chronic HCV or indicate serious concerns such as hepatitis B reactivation, which is discussed below.

While rare, serious side effects may develop in certain patients taking Mavyret. These include:

• Reactivation of hepatitis B virus* in individuals with a history of HBV
• Allergic reactions

For in-depth information regarding these serious side effects, see the “Side Effects Explained” section below. It’s crucial to consult with your healthcare provider if you experience any new or worsening symptoms. In case of life-threatening symptoms, seek immediate medical attention.

Do Mavyret and Other Medications Interact?

Yes, Mavyret can interact with various medications, including:

• Warfarin (a blood thinner)
• Carbamazepine (for seizures)
• Digoxin (for heart failure)
• Birth control pills containing ethinyl estradiol
• Rifampin (an antibiotic)
• Certain HIV antivirals like atazanavir and efavirenz
• Statins for lowering cholesterol, such as atorvastatin and rosuvastatin

Additional interactions and a comprehensive review should be conducted with your healthcare provider before starting Mavyret.

Can Side Effects Persist After Stopping Mavyret?

Yes, lingering side effects such as hepatitis B reactivation may occur post-treatment, particularly in individuals with previous HBV history. These reactions can lead to serious complications like severe liver damage. Ensure to inform your doctor about any previous HBV infections before starting treatment.

Will Mavyret Make Me Feel Ill?

Patients may experience nausea, fatigue, headaches, or diarrhea—common side effects that may cause discomfort. It's important to consult your doctor regarding any severe persistence of these symptoms.

Duration of Mavyret Side Effects?

Typically, mild side effects last for the treatment duration, which generally ranges from 8 to 16 weeks. Any persistent symptoms upon completion should warrant medical evaluation.

Can Mavyret Cause Hair Loss?

No, hair loss is not a reported side effect of Mavyret. Unlike interferons, which were previously used to treat HCV, Mavyret does not affect hair growth.

Hepatitis B Reactivation

Mavyret has a boxed warning indicating the potential for previous HBV to reactivate, which can lead to severe or fatal liver damage if not monitored properly. Inform your physician of any past HBV history to establish a suitable monitoring plan.

Itching

Itching can occur among individuals taking Mavyret and may indicate worsening liver conditions or HBV reactivation. Discuss options with your healthcare provider to manage this symptom effectively.

Fatigue

Fatigue is a common experience during Mavyret treatment and may be exacerbated if you’ve experienced HBV flare-ups. If severely affecting daily activities, contact your medical professional for advice.

Headaches

Headaches can develop and should be managed carefully, especially to avoid medications harmful to the liver. Consult your doctor if headaches interfere with your quality of life.

Allergic Reactions

Allergic responses, ranging from mild skin rashes to severe manifestations, can occur. Mild reactions may be managed with medications like antihistamines, while severe cases require immediate medical intervention.

Warnings for Mavyret

Questions to Discuss with Your Doctor

Before starting Mavyret, prepare a list of inquiries to discuss with your healthcare provider:

• Am I at increased risk for side effects with Mavyret?
• How can I monitor for reactivation of hepatitis B?
• Do existing conditions like HIV raise my risk with Mavyret?
• What interactions should I be aware of if taking statins with Mavyret?
• How should I manage mild gastrointestinal issues during treatment?

For further information regarding Mavyret, consult your medical professional or explore additional resources.