Prolia, known generically as denosumab, is a prescription medication primarily used to treat osteoporosis and enhance bone strength in individuals at high risk for fractures. While Prolia is effective, it is important to be aware of its potential interactions with various medications and substances, including corticosteroids like hydrocortisone.

This medication is particularly prescribed for:

• Osteoporosis treatment in men and postmenopausal women
• Osteoporosis linked to corticosteroid therapy
• Bone strengthening for patients receiving specific treatments for prostate or breast cancer

Prolia is administered as a liquid solution injection, performed by a healthcare professional. Understanding drug interactions is crucial as they can alter how medications behave in your body, potentially leading to unexpected effects. Continue reading to explore Prolia's interactions thoroughly.

Before starting Prolia, it’s essential to inform your healthcare provider about any other prescriptions, over-the-counter medications, or supplements you are using. This information helps to prevent adverse interactions. For a comprehensive understanding of Prolia's drug interactions, refer to the table below, which highlights known interactions (not exhaustive).

There are certain health conditions that may increase the risks associated with taking Prolia. These are referred to as contraindications and include:

• Low Calcium Levels: If you currently have low calcium levels, your doctor will address this with supplements before starting Prolia.
• Pregnancy: Prolia may harm a fetus, so it’s typically not advised for pregnant individuals.
• Allergic Reactions: A history of allergic reactions to Prolia or its components precludes its use.

Discuss these factors with your healthcare provider to evaluate whether Prolia is appropriate for you.

Currently, there are no known interactions between Prolia and alcohol. However, it’s always best to consult your doctor or pharmacist if you have any concerns about alcohol consumption during your treatment with Prolia.

Corticosteroid Interaction

Corticosteroids, used for reducing inflammation, can elevate the risk of certain side effects if taken with Prolia:

• Hydrocortisone (Solu-Cortef)
• Methylprednisolone (Medrone)

Risk Overview

Using Prolia with corticosteroids can increase the likelihood of infections and rare side effects such as osteonecrosis of the jaw, which can lead to dental issues. Maintaining strong oral hygiene is crucial.

Bisphosphonate Interaction

Examples include:

• Alendronate (Fosamax)
• Risedronate (Actonel)

Risk Overview

Both Prolia and bisphosphonates can lead to low calcium levels, and the combined use may enhance the risk of dental problems.

Immunosuppressant Interaction

These medications, including:

• Adalimumab (Humira)
• Infliximab (Remicade)

Risk Overview

Taking Prolia concurrently with immunosuppressants may increase infection risks.

Supplements

Before starting Prolia, discuss any herbs, vitamins, or supplements you take with your doctor to avoid interactions. Currently, no known interactions exist with herbs or vitamins, but caution is advised.

Dietary Considerations

No current interactions have been reported between Prolia and food. Consult your healthcare provider for personalized dietary advice.

Vaccines and Lab Tests

There are no known interactions between Prolia and vaccines or lab tests. Always communicate with your healthcare provider about any vaccines or tests while on Prolia.

Your health history can significantly influence the safety of Prolia treatment. Discuss the following conditions with your doctor:

• Existing low calcium levels
• History of thyroid or parathyroid surgical procedures
• Mineral absorption difficulties
• Chronic kidney disease (CKD)
• Dental or oral health issues
• Pregnancy or plans to become pregnant
• Allergic reactions to Prolia or its ingredients

Can Prolia be taken with antibiotics?

Yes, there are no known interactions. However, since calcium supplements can interact with certain antibiotics, consult your doctor to ensure proper timing.

Is there an interaction between Prolia and statins?

Prolia and statins do not have any known interactions, making it safe to use them together.

To mitigate interaction risks with Prolia:

• Disclose your complete medication history to healthcare providers.
• Understand Prolia's literature on potential interactions.
• Take Prolia strictly as prescribed.

If you have further questions about Prolia and its interactions, consider asking:

• Should I stop Prolia if surgery is required?
• Can I take over-the-counter pain relievers during my Prolia treatment?
• Should changes in my diet or lifestyle be reported while on Prolia?