Understanding the Side Effects of Ocrevus: Essential Information for Patients

Common Side Effects of Ocrevus

During your treatment with Ocrevus, you may experience a number of side effects. Some of the more frequently reported side effects include:

• Infusion reactions*
• Upper respiratory infections*
• Lower respiratory infections*
• Skin infections*†

For further details on these side effects, please see the in-depth section titled “Side Effects Explained” below.

† This particular side effect was noted primarily in studies involving individuals diagnosed with primary progressive MS; it remains uncertain whether it also appears in those with relapsing-remitting MS.

What Mild Side Effects May Occur?

Mild side effects that have been reported in individuals treated with Ocrevus for MS or clinically isolated syndrome include:

• Upper respiratory infections*
• Lower respiratory infections*
• Herpes infections*†

Additional mild side effects noted in patients with primary progressive MS include:

• Skin infections*
• Cough
• Diarrhea*
• Swelling in the legs, feet, arms, or hands

For those undergoing treatment for relapsing forms of MS, mild side effects might also include:

• Depression
• Back, arm, or leg pain

Generally, these side effects are expected to resolve on their own within a short period, and many can be managed with supportive care. However, if you experience ongoing or bothersome symptoms, it’s crucial to consult your healthcare provider before discontinuing Ocrevus.

Serious Side Effects of Ocrevus

Although Ocrevus is effective, it can lead to serious side effects, including:

• Infusion reactions*
• Serious bacterial, viral, and fungal infections, including reactivation of hepatitis B or herpes infections*†
• Progressive multifocal leukoencephalopathy (a severe central nervous system infection)
• Colitis (inflammation of the colon)
• Increased risk of certain cancers*
• Allergic reactions*‡

If you experience serious side effects while being treated with Ocrevus, seek medical attention immediately. In the case of life-threatening side effects, call emergency services right away.

† Herpes and hepatitis B infections specifically affect individuals with prior exposure to these viruses.
‡ Although allergic reactions have been documented, it remains unclear how frequently they occur in clinical studies.

Frequently Asked Questions about Ocrevus’s Side Effects

Will I Gain Weight While on Ocrevus?

Weight gain is unlikely during Ocrevus treatment. In studies, it was not a commonly reported side effect among MS patients. However, some individuals with primary progressive MS have reported swelling in their limbs, which can sometimes contribute to weight gain. Consult your physician if you notice any significant changes in your weight.

Can I Expect Hair Loss?

The correlation between Ocrevus and hair loss remains undetermined. While it has not been reported as a side effect of Ocrevus, some medications for MS can cause hair loss. If this becomes a concern, discuss it with your doctor.

Are There Long-term Side Effects of Ocrevus?

Ocrevus works by suppressing immune function, which can increase the risk of infections. This elevated risk may persist for an extended period, even after discontinuation. It is essential to practice infection prevention strategies during and post-treatment.

How Long Might Side Effects Last?

Most side effects generally resolve within a few days to a couple of weeks. If you develop an infection or infusion reaction, additional treatment may be necessary. Please consult your doctor if side effects persist or worsen.

Are Eye-Related Side Effects Possible?

Eye-related side effects are rare but not impossible. Recurrent herpes infections associated with Ocrevus could occasionally affect the eyes. Seek medical attention promptly if you experience eye pain, redness, or changes in vision while undergoing treatment.

Is Joint Pain Associated with Ocrevus Use?

Joint pain is not a documented side effect of Ocrevus. Nevertheless, some patients have reported pain in limbs or the back, which can be attributed to MS itself. If joint pain occurs, consult your doctor for potential underlying causes.

In-Depth Look at Ocrevus Side Effects

Fatigue

Fatigue is a common symptom of MS and is not mainly caused by Ocrevus, unless it occurs during an infusion reaction. Ensure you communicate any fatigue to your healthcare provider for appropriate management strategies.

Increased Cancer Risk

Ocrevus may slightly raise the risk for cancer due to its immune-suppressing effects. Regular wellness check-ups and screenings, including mammograms for women over 45, are crucial for early detection.

Diarrhea

Diarrhea has been reported in individuals using Ocrevus, especially with primary progressive MS. Stay hydrated and consult your doctor if diarrhea is persistent or severe.

Infections

Due to immune suppression, Ocrevus can increase vulnerability to infections, such as respiratory and skin infections. Maintain good hygiene and report any infection symptoms promptly to your doctor.

Infusion Reactions

Reactions may occur during or shortly after Ocrevus infusion. Symptoms can include rash, itching, shortness of breath, and fever. Medical personnel will monitor you during infusions to manage any reactions effectively.

Allergic Reactions

Allergic reactions range from mild to severe. Contact your healthcare provider immediately if you experience any severe symptoms such as difficulty breathing or substantial swelling.

Consulting Your Doctor

If you have questions regarding Ocrevus and its potential side effects, do not hesitate to reach out to your healthcare provider. Here are some questions you may consider asking:

• How do the side effects of Ocrevus compare to other MS treatments?
• What measures are in place if I have a serious infusion reaction?
• Are there specific vaccines I should receive before starting treatment?
• Does this medication pose any special risks for COVID-19 infection or vaccination?

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Disclaimer: This information is intended for educational purposes. It should not be substituted for professional medical advice. Always consult your healthcare provider regarding any medical decisions.