Apedom 10 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Apollo pharmaceutical ltd |
| Also available as |
Title
- Apedom 10 mg Tablet
Categories
- Medicine
- Pharmaceuticals
- Gastroenterology
Description
- A dopamine antagonist medication for the treatment of nausea and vomiting, dyspepsia, delayed gastric emptying, gastroesophageal reflux, esophagitis, and as a prokinetic agent for radiological studies
Dimensions
- Standard tablet size
Color Options
Functions
- Relieves nausea and vomiting
- Improves dyspeptic symptoms
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Restores normal motility and tone of the upper gastrointestinal tract
Materials
- Domperidone (active ingredient)
- Various inactive ingredients for tablet formulation
Technical Specifications
- Molecular Formula: C22H24ClN5O2
- Chemical Structure: Image available
Design Elements
- Tablet form
- Clear packaging for visibility
Usability Features
- Suitable for adults and children
- Can be taken before meals or retiring
- Available in suspension form for pediatric use
Dosage & Administration
- Adults: 10-20 mg, every 6-8 hours daily (maximum of 80 mg daily)
- Children: 2-4 ml suspension/10 kg body weight, every 6-8 hours daily (pediatric drops available)
- Rectal administration for adults and children
Indications
- Relief of dyspeptic symptoms
- Treatment of acute nausea and vomiting
- Use in Parkinson's disease for dopamine-agonist induced nausea and vomiting
- Speeding barium transit in follow-through radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in the CTZ and stomach
- Restores normal motility and tone of the upper gastrointestinal tract
- Weak penetration across the blood-brain barrier
Interaction
- Antagonized by anticholinergic drugs
- Not to be given simultaneously with antacids and antisecretory drugs
- Metabolized through CYP3A4 pathway
- Potential influence on absorption of concomitantly orally administered drugs
Contraindications
- Hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage, mechanical obstruction, or perforation
- Prolactin releasing pituitary tumor
Side Effects
- Rare occurrence of transient intestinal cramps
- Rare extrapyramidal phenomena, especially in children
- Possible induction of hyperprolactinaemia
- Rare allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Caution in use during the first trimester of pregnancy
- Excretion in breast milk, caution advised for nursing mothers
Precautions & Warnings
- Caution in use with children due to risk of extra-pyramidal reactions
- Use with caution in patients with hepatic impairment
Use in Special Populations
- Caution advised in infants and patients with liver or kidney disorders
Overdose Effects
- Symptoms include drowsiness, disorientation, and extrapyramidal reactions
- Administration of activated charcoal and close observation recommended
Therapeutic Class
- Motility Stimulants
- Motility stimulants/Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach