Apuldon 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Aristopharma ltd |
| Also available as |
Title and Categories
- Brand Name: Apuldon 5 mg/5 ml Suspension
- Therapeutic Class: Motility Stimulants, Dopamine antagonist, Prokinetic drugs
Indications & Usage
- Treatment for dyspeptic symptom complex
- Treatment for delayed gastric emptying
- Treatment for gastroesophageal reflux
- Treatment for esophagitis
- Management of acute nausea and vomiting
- Management of nausea and vomiting induced by radiotherapy
- Management of nausea and vomiting induced by drug therapy
- Management of nausea and vomiting induced in migraine
- Treatment for nausea and vomiting in Parkinson's disease
- Radiological studies: Speeding barium transit in follow-through radiological studies
Pharmacology
- Domperidone is a dopamine antagonist
- Blocks dopamine receptors in the Chemoreceptor Trigger Zone
- Blocks dopamine receptors in the stomach
- Restores normal motility and tone of the upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Increases lower esophageal sphincter pressure
Dosage & Administration
- Administered 15-30 minutes before meals
- Usual recommended oral dose for adults: 10-20 mg every 6-8 hours daily
- Maximum dose for adults: 80 mg daily
- Dosage for children based on body weight
- Rectal administration available with specific dosages
Interaction
- Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect of domperidone
- Avoid simultaneous administration with antacids and antisecretory drugs
- Metabolic pathway via CYP3A4
- Potential drug interactions with CYP3A4 inhibitors
- Interaction with neuroleptics and dopaminergic agonists
Contraindications
- Hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Rare increase in plasma prolactin level
- Rare allergic reactions
- Possible neuroendocrinological phenomena
- Rare rash and urticaria
Pregnancy & Lactation
- Use during first trimester justified by therapeutic benefit
- No evidence of increased risk of malformations in humans
- Excretion in breast milk
- Lower domperidone concentrations in breast milk compared to plasma
- Not recommended for nursing mothers unless benefits outweigh potential risks
Precautions & Warnings
- Caution in use for children
- Increased risk of extra-pyramidal reactions in young children
- Caution in use for patients with hepatic impairment
Use in Special Populations
- Caution in use for infants
- Liver disorder caution
- Kidney disorder caution
- Review of patients on prolonged therapy
Overdose Effects
- Symptoms include drowsiness, disorientation, and extrapyramidal reactions
- Activated charcoal administration recommended
- Close patient observation advised
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image available
Commonly Asked Questions
- Use to relieve nausea, vomiting, and indigestion
- Dosage and duration specified by a doctor
- Possible side effects include dizziness and sleepiness
- Avoid alcohol consumption during treatment
- Dry mouth may occur as a side effect
- Consult a doctor if symptoms persist beyond 7 days