Beridom 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 28.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Belsen pharmaceuticals ltd |
| Also available as |
Title
- Beridom 5 mg/5 ml Suspension
Category
- Medication
- Pharmaceutical
Description
- Dopamine antagonist medication
- Treats nausea and vomiting
Color Options
- No specific color options
Dosage Form
- Tablet
- Suspension
- Paediatric drops
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Adult dose: 10-20 mg (1-2 tablets or 10-20 ml suspension)
- Children's dose: 0.2-0.4 mg/kg body weight
- Maximum dose: 80 mg daily
- Route of administration: Oral, Rectal (suppositories)
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiotherapy-induced nausea and vomiting
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in CTZ and stomach
- Gastroprokinetic action
- Restores normal motility and tone of upper GI tract
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Weak penetration across blood-brain barrier
Interaction
- Anticholinergic drugs may antagonize domperidone's effect
- Avoid simultaneous administration with antacids and antisecretory drugs
- Main metabolic pathway through CYP3A4
- In vitro data suggests interaction with CYP3A4 inhibitors
Contraindications
- Known hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor
Side Effects
- Transient intestinal cramps
- Extrapyramidal phenomena
- Increase in plasma prolactin level
- Neuroendocrinological phenomena
- Galactorrhea
- Gynecomastia
- Rare allergic reactions (rash, urticaria)
Pregnancy & Lactation
- Can be used during the first trimester if justified by therapeutic benefit
- Excreted in breast milk (concentrations lower than plasma)
- Nursing not recommended unless benefits outweigh risks
- Does not affect mental alertness
Precautions & Warnings
- Caution in children due to risk of extra-pyramidal reactions
- Use with caution in hepatic impairment
Use in Special Populations
- Caution in infants due to incomplete blood-brain barrier
- Caution in hepatic impairment
- Caution in severe renal insufficiency
Overdose Effects
- Symptoms: drowsiness, disorientation, extrapyramidal reactions
- Administration of activated charcoal recommended
Therapeutic Class
- Motility Stimulants
- Dopamine Antagonist
- Prokinetic Drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Image of Chemical Structure provided
Medical Uses
- Relief of dyspeptic symptoms
- Treatment of acute nausea and vomiting
- Parkinson's disease-induced nausea and vomiting
- Speeding barium transit in radiological studies
Usability
- Oral administration
- Rectal administration (suppositories)
Technical Specifications
- Maximum daily dose: 80 mg
- Dosing frequency may need to be reduced in renal insufficiency
Design Elements
- Tablet form
- Suspension form
- Paediatric drops
Materials
- Active ingredient: Domperidone
- Metabolized in the liver
Functions
- Gastroprokinetic action
- Restoration of normal motility and tone of upper GI tract
Dimensions
- Tablet dimensions (if available)