Cosy 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 28.19

Medicine Details

Category Details
Generic Domperidone maleate
Company Orion pharma ltd
Also available as
Cosy 10 mg tablet

Title

  • Cosy 5 mg/5 ml Suspension

Categories

  • Medicine
  • Pharmaceutical
  • Healthcare

Description

  • Dopamine antagonist medication for treating nausea and vomiting
  • Gastrointestinal motility stimulant
  • Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and the stomach
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying and enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis and lower esophageal sphincter pressure
  • Does not affect the mental alertness
  • Rapid barium transit in follow-through radiological studies

Color Options

  • White

Dosage & Administration

  • For adults: 10-20 mg (1-2 tablets or 10-20 ml suspension) every 6-8 hours daily
  • Maximum daily dose for adults is 80 mg
  • Children's dosage is based on body weight and age

Indications

  • Treatment of dyspeptic symptom complex
  • Management of acute nausea and vomiting
  • Use in Parkinson's disease
  • Speeding barium transit in radiological studies

Pharmacology

  • Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach
  • Gastroprokinetic action based on blocking effect of dopamine receptors
  • Weak penetration across the blood-brain barrier
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying and enhances antral and duodenal peristalsis
  • Increases esophageal peristalsis and lower esophageal sphincter pressure

Interaction

  • Antagonized by anticholinergic drugs
  • Should not be given simultaneously with antacids and antisecretory drugs
  • Metabolism primarily through CYP3A4 pathway
  • Inhibited by drugs such as azole antifungals and macrolide antibiotics

Contraindications

  • Hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Possible increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Use during first trimester if justified by therapeutic benefit
  • Excreted in breast milk, caution advised during nursing

Precautions & Warnings

  • Use with caution in children and hepatic impairment

Use in Special Populations

  • Caution in infants and under close medical supervision
  • Use with caution in liver and kidney disorders

Overdose Effects

  • Drowsiness, disorientation, and extrapyramidal reactions
  • Recommended management with activated charcoal and close observation

Therapeutic Class

  • Motility stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C, protected from light & moisture

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions

  • Used for treating nausea and vomiting
  • Quick tips for usage and potential side effects

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