Dompen 10 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Millat pharmaceuticals ltd |
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Functional nausea and vomiting
- Nausea and vomiting induced by radiotherapy
- Nausea and vomiting induced by drug therapy
- Nausea and vomiting induced in migraine
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Chemoreceptor Trigger Zone (CTZ) blocker
- Gastroprokinetic action
- Gastrointestinal motility regulator
- Gastric emptying facilitator
- Upper gastrointestinal tract normalizer
- Esophageal peristalsis enhancer
- Pylorus contraction regulator
- Dopaminergic receptor blocker
- Blood-brain barrier weakly penetrable
Dosage & Administration
- Usual recommended oral dose for adults and children
- Administration before meals and if necessary before retiring
- Dosage adjustment for dyspeptic symptoms
- Dosage adjustment for acute and sub-acute conditions
- Rectal administration dosage for adults and children
- Maximum daily dosage
- Maximum period of treatment
Interaction
- Anticholinergic drug antagonism
- Antacid and antisecretory drug interaction
- Metabolic pathway through CYP3A4
- CYP3A4 inhibitors
- Possible influence on absorption of orally administered drugs
- No influence on neuroleptics
- Absence of potentiation of dopaminergic agonists
Contraindications
- Known hypersensitivity
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Potential increase in plasma prolactin level
- Rare allergic reactions including rash and urticaria
Pregnancy & Lactation
- Use in the first trimester of pregnancy if justified by therapeutic benefit
- No evidence of increase in the risk of malformations in humans
- Excretion in breast milk
- Not recommended during lactation
Precautions & Warnings
- Increased risk of extra-pyramidal reactions in young children
- Caution in patients with hepatic impairment
- Use with caution in infants
- Use with caution in liver disorders
- Use with caution in kidney disorders
- Regular review for patients on prolonged therapy
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Caution in liver disorders
- No need to adjust single acute administration dose in patients with severe renal insufficiency
- Need for dosing frequency and dose adjustment on repeated administration
Overdose Effects
- Symptoms of overdosage
- Recommendations for treatment in case of overdosage
- Use of anticholinergic, antiparkinson, or antihistamine drugs
Therapeutic Class
- Motility Stimulants
- Dopamine Antagonists
- Prokinetic Drugs
Storage Conditions
- Temperature and environmental storage instructions
- Protection from light and moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula
- Chemical Structure Image
Common Questions about Dompen 10 mg Tablet
- Uses of Dompen 10 mg Tablet
- Quick Tips for taking Dompen 10 mg Tablet