Alfasin XR 10 mg (Tablet (Extended Release))

Indications

• Treatment of benign prostatic hyperplasia (BPH)
• Lower urinary tract symptoms (LUTS) including urinary frequency
• Nocturia
• Incomplete emptying
• Urinary hesitancy

Pharmacology

• Selective antagonist of post-synaptic a1 adrenoreceptors
• Relaxes prostate smooth muscle
• Blocks prostatic a1 receptors
• Reduces resting urethral pressure

Dosage

• Recommended dose: 10 mg once daily after a meal for BPH
• 10 mg daily for acute urinary retention in patients 65 years and older

Administration

• Tablet should be swallowed whole

Interaction

• Contraindicated with alpha-1-receptor blockers
• To be taken into account with antihypertensive drugs, nitrates, potent CYP3A4 inhibitors like ketoconazole
• Potential interaction with general anaesthetics

Contraindications

• Postural hypotension in some subjects
• Caution in patients with acute cardiac failure
• Hypersensitivity to alpha-1-blockers
• Careful administration to patients being treated with antihypertensives

Side Effects

• Common: faintness/dizziness, headache
• Uncommon: syncope, malaise, vision abnormalities
• Rare: New onset, aggravation or recurrence of angina pectoris
• General: asthenia, chest pain

Pregnancy & Lactation

• Not applicable due to indication

Precautions & Warnings

• Administration of general anesthetics could cause profound hypotension
• Stop if symptoms of angina pectoris start or worsen

Use in Special Populations

• Not demonstrated for children aged 2 to 16 years

Overdose Effects

• Patient should be hospitalised
• Conventional treatment of hypotension should take place
• Appropriate corrective treatment may be a vasoconstrictor

Therapeutic Class

• BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

• Store in a cool and dry place, protected from light

Related Brands

• Alfumax ER 10 mg (Tablet (Extended Release)) - unimed-unihealth-pharmaceuticals-ltd
• Zatral 10 mg (Tablet (Extended Release)) - eskayef-pharmaceuticals-ltd