Gidonic 10 mg (Tablet)
Unit Price: ৳ 2.01 (100's pack: ৳ 201.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Novelta bestway pharma ltd |
| Also available as |
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors
- Gastroprokinetic action
- Weak penetration across blood-brain barrier
- Restores normal motility and tone of upper gastrointestinal tract
- Facilitates gastric emptying
- Increases esophageal peristalsis
Dosage & Administration
- Taken 15-30 minutes before meals
- Usual recommended oral dose for adults: 10-20 mg every 6-8 hours
- Usual recommended oral dose for children: 2-4 ml suspension/10 kg body weight every 6-8 hours
- Maximum dose for adults: 80 mg daily
- Maximum period of treatment is 12 weeks
Interaction
- Antagonizes antidyspeptic effect of anticholinergic drugs
- Should not be given simultaneously with antacids and antisecretory drugs
- Main metabolic pathway is through CYP3A4
- Concomitant use of CYP3A4 inhibitors may result in increased plasma levels
- Influences the absorption of orally administered drugs
- Does not potentiate action of neuroleptics
- Suppresses unwanted peripheral effects of dopaminergic agonists
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Extrapyramidal phenomena rare in young children
- Increase in plasma prolactin level
- Rare cases of hyperprolactinaemia resulting in neuroendocrinological phenomena such as galactorrhoea and gynaecomastia
- Rare allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Should be used during the first trimester of pregnancy with caution if justified by anticipated therapeutic benefit
- No evidence of increase in the risk of malformations in humans
- Excreted in breast milk of lactating rats
- Concentrations in breast milk 4 times lower than corresponding plasma concentrations
- Nursing not recommended unless expected benefits outweigh potential risk
- Does not affect mental alertness
Precautions & Warnings
- Use with caution in children due to increased risk of extra-pyramidal reactions
- Use with caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Use with caution in liver disorders
- Use with caution in kidney disorders
Overdose Effects
- Symptoms may include drowsiness, disorientation, extrapyramidal reactions
- Administration of activated charcoal recommended
- Close observation of patients recommended
- Anticholinergic, antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Motility stimulants/Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure: Image of chemical structure
Commonly Asked Questions about Gidonic 10 mg Tablet
- Used to treat nausea and vomiting
- Helps relieve nausea, vomiting and indigestion
- Caution in driving or activities requiring mental focus
- Avoid alcohol consumption
- Possible side effects include dry mouth, watery diarrhea, fever, or stomach pain
- Consult doctor if taking longer than 7 days