Motodon 10 mg (Tablet)

Unit Price: ৳ 1.50 (100's pack: ৳ 150.00)

Medicine Details

Category Details
Generic Domperidone maleate
Company Medimet pharmaceuticals ltd
Also available as
Motodon 10 mg tablet

Title, Categories and Description

  • Domperidone 10 mg Tablet - Dopamine Antagonist for Nausea and Vomiting Relief

Product Form

Tablet

Dosage Form

Oral

Packaging Options

  • Bottle
  • Blister Pack

Dosage Strength

10 mg

Therapeutic Class

  • Motility Stimulants
  • Dopamine Antagonist
  • Prokinetic Drugs

Indications

  • Relief of dyspeptic symptom complex
  • Treatment of acute nausea and vomiting
  • Used in Parkinson's disease for dopamine-agonist induced nausea and vomiting
  • Speeding barium transit in radiological studies

Mode of Action

Dopamine antagonist, primarily blocking receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach

Pharmacological Actions

  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis
  • Enhances lower esophageal sphincter pressure

Dosage & Administration

  • Adults: 10-20 mg every 6-8 hours daily, maximum 80 mg daily
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight every 6-8 hours daily

Interaction

  • Concomitant administration with anticholinergic drugs may antagonize its effect
  • Antacids and antisecretory drugs should not be given simultaneously
  • Concomitant use of drugs that significantly inhibit CYP3A4 may increase plasma levels of domperidone
  • May influence absorption of orally administered drugs, particularly sustained release or enteric coated formulations
  • Does not potentiate action of neuroleptics
  • Suppresses unwanted peripheral effects of dopaminergic agonists

Contraindications

  • Known hypersensitivity
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Possible increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Should only be used during the first trimester if justified by therapeutic benefit
  • Excreted in breast milk, caution advised

Precautions & Warnings

  • Caution in children due to risk of extra-pyramidal reactions
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Infants: Caution and close medical supervision due to immature blood-brain barrier
  • Liver Disorders: Caution due to high metabolism in the liver
  • Kidney Disorders: Dosing frequency may need to be reduced in severe renal insufficiency

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions

Storage Conditions

Store below 30°C, protect from light & moisture, keep out of children's reach

Compound Summary

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure: Image of chemical structure provided

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