Motigut 10 mg (Tablet)
Unit Price: ৳ 3.50 (10 x 10: ৳ 350.00)
Strip Price: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Square pharmaceuticals plc |
| Also available as |
Title
- Motigut 10 mg Tablet
Categories
- Medicine
- Pharmaceutical
Description
- A medication used for the treatment of dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and as an aid in radiological studies. It is a dopamine antagonist with gastroprokinetic action.
Dosage Form
- Tablet
- Suspension
Dosage Strength
- 10 mg
- 20 mg
- 30-60 mg (suppository)
Dosage Frequency
- Every 6-8 hours daily
- Before meals
- Before retiring
Recommended Dose for Adults
- 10-20 mg
- 20 mg
- 30-60 mg rectally every 4-8 hours
Maximum Daily Dose
- 80 mg for adults
Recommended Dose for Children
- 2-4 ml suspension/10 kg body weight
- 0.4-0.8 ml pediatric drops/10 kg body weight
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Acute nausea and vomiting
- Parkinson's disease
- Radiotherapy-induced nausea and vomiting
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in the CTZ and stomach
- Restores normal motility and tone of upper gastrointestinal tract
- Enhances antral and duodenal peristalsis
- Increases esophageal peristalsis and lower esophageal sphincter pressure
Interaction
- Antagonized by anticholinergic drugs
- Lowered oral bioavailability when given with antacids or antisecretory drugs
- Metabolized through CYP3A4 pathway
- Potential effects on absorption of concomitantly orally administered drugs
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor
Side Effects
- Transient intestinal cramps
- Extrapyramidal phenomena (rare)
- Increase in plasma prolactin level
- Rare allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Use only during the first trimester if justified by therapeutic benefit
- Excreted in breast milk at lower concentrations than in plasma
- Not recommended during nursing unless benefits outweigh risks
Precautions & Warnings
- Caution in children due to risk of extra-pyramidal reactions
- Caution in patients with hepatic impairment
Use in Special Populations
- Caution when given to infants due to immature blood-brain barrier
- Caution in patients with hepatic impairment
- Dosing adjustment may be required in severe renal insufficiency
Overdose Effects
- Symptoms may include drowsiness, disorientation, extrapyramidal reactions
- Administration of activated charcoal recommended
- Anticholinergic or antihistamines may help control extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light and moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Used to treat nausea and vomiting
- Helps relieve indigestion
- May cause dizziness and sleepiness
- Avoid alcohol consumption
- Side effects may include dry mouth and watery diarrhea