Motigut 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 40.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Square pharmaceuticals plc
Also available as
Motigut 10 mg tablet Motigut 5 mg pediatric drop

Product title

  • Motigut 5 mg/5 ml Suspension

Therapeutic class

  • Motility Stimulants
  • Motility stimulants/Dopamine antagonist
  • Prokinetic drugs

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux and esophagitis
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Pharmacology

  • Dopamine antagonist
  • Blocks dopamine receptors in the ChemoreceptorTrigger Zone (CTZ) and stomach
  • Gastroprokinetic action
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis and lower esophageal sphincter pressure

Dosage administration

  • Recommended to be taken 15-30 minutes before meals
  • Adults: 10-20 mg every 6-8 hours daily
  • Children: 2-4 ml suspension/10 kg body weight every 6-8 hours daily
  • Maximum dose of 80 mg daily for adults
  • Maximum period of treatment is 12 weeks
  • Rectal administration for adults and children

Interaction

  • Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect
  • Antacids and antisecretory drugs should not be given simultaneously
  • Metabolic pathway through CYP3A4
  • Inhibition by drugs such as azole antifungals, macrolide antibiotics, HIV protease inhibitors
  • Potential influence on absorption of concomitantly orally administered drugs
  • Does not potentiate action of neuroleptics and dopaminergic agonists

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy lactation

  • Should only be used during the first trimester if justified by therapeutic benefit
  • Excreted in breast milk
  • Not recommended during nursing

Precautions warnings

  • Use with caution in children and patients with hepatic impairment

Special populations uses

  • Use with caution in infants under 1 year of age
  • Use with caution in patients with hepatic impairment
  • Dosing frequency adjustment for patients with severe renal insufficiency

Overdose effects

  • Symptoms may include drowsiness, disorientation, extrapyramidal reactions
  • Recommendation of activated charcoal and close patient observation

Storage conditions

  • Store below 30°C
  • Protected from light and moisture
  • Keep out of children's reach

Chemical structure

  • Molecular Formula: C22H24ClN5O2

Common questions

  • Used to treat nausea and vomiting
  • Helps relieve indigestion
  • May cause dizziness and sleepiness

Functionality

  • Relieves dyspeptic symptoms
  • Regulates gastric emptying
  • Enhances gastrointestinal motility
  • Blocks dopamine receptors in specific zones
  • Inhibits certain enzyme pathways
  • May antagonize certain drug effects

Administration route

  • Oral
  • Rectal

Dosage recommendations

  • 10-20 mg for adults every 6-8 hours daily
  • 2-4 ml suspension/10 kg body weight for children every 6-8 hours daily

Potential interactions

  • Anticholinergic drugs
  • Antacids and antisecretory drugs
  • Drugs that inhibit CYP3A4
  • Orally administered drugs with special formulations

Contraindications info

  • Hypersensitivity to the drug
  • Neonates
  • Certain gastrointestinal conditions
  • Prolactin releasing pituitary tumor

Adverse effects

  • Intestinal cramps
  • Extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Allergic reactions such as rash and urticaria

Pregnancy lactation info

  • Use only in first trimester when justified
  • Excreted in breast milk at lower concentrations than plasma

Special precautions

  • Caution in children and hepatic impairment patients
  • Close medical supervision for infants

Overdose symptoms

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions

Chemical formula

C22H24ClN5O2

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