Motilex 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 40.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Techno drugs ltd
Also available as
Motilex 10 mg tablet

Primary Indications

  • Dyspeptic symptom complex
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Secondary Indications

  • Functional, organic, infectious, dietetic origin nausea and vomiting
  • Nausea and vomiting induced by radiotherapy or drug therapy or induced in migraine

Pharmacological Action

  • Dopamine antagonist
  • Blocks dopamine receptors in the ChemoreceptorTrigger Zone (CTZ) and stomach
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis

Dosage Form

  • Tablet
  • Suspension
  • Paediatric drops
  • Suppositories

Adult Dosage

  • 10-20 mg every 6-8 hours daily for dyspeptic symptom
  • 20 mg every 6-8 hours daily for acute and sub-acute conditions
  • 30-60 mg every 4-8 hours by rectum in suppositories

Children Dosage

  • 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight every 6-8 hours daily
  • 0.2-0.4 mg/kg body weight every 6-8 hours daily for dyspeptic symptom
  • 0.2-0.4 mg/kg body weight every 6-8 hours daily for acute and sub-acute conditions
  • The maximum daily dose rectally in children's is 30 mg for those weighing 10 to 25 kg

Interactions

  • Anticholinergic drugs
  • Antacids and antisecretory drugs
  • CYP3A4 inhibitors
  • Neuroleptics
  • Dopaminergic agonists

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Can be used during the first trimester if justified by therapeutic benefit
  • Excreted in breast milk but lower concentrations compared to plasma
  • Nursing not recommended unless benefits outweigh potential risks

Precautions

  • Caution in children due to risk of extra-pyramidal reactions
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Use in infants with caution and under close medical supervision
  • Caution in patients with liver or kidney disorders

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions
  • Activated charcoal may be helpful in controlling the reactions

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light & moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions

  • What is Motilex 5 mg/5 ml Suspension used for?
  • Tips for using Motilex 5 mg/5 ml Suspension

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