Peridone 10 mg (Tablet)
Unit Price: ৳ 2.00 (3 x 10: ৳ 60.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Astra biopharmaceuticals ltd |
| Also available as |
Title
- Peridone 10 mg Tablet
Categories
- Medicine
- Gastrointestinal
- Prokinetic
Description
- Dyspeptic symptom relief
- Treatment of acute nausea and vomiting
- Management of Parkinson's disease-induced nausea and vomiting
- Aiding in radiological studies by speeding barium transit
Dimensions
- Standard tablet size (10 mg)
Color Options
- White
Functions
- Dopamine antagonist
- Gastroprokinetic action
- Enhances gastric emptying
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Facilitates motility and tone of upper gastrointestinal tract
Materials
- Domperidone
Technical Specifications
- Usual recommended oral dose for adults: 10-20 mg every 6-8 hours (maximum dose of 80 mg daily)
- Usual recommended oral dose for children: 2-4 ml suspension/10 kg body weight every 6-8 hours
- Rectal administration: 30-60 mg every 4-8 hours for adults
Design Elements
- Film-coated tablet
- Suspension form
- Paediatric drops for children
Usability Features
- Should be taken 15-30 minutes before meals
- Can be taken before retiring if necessary
Interactions
- Antagonism with anticholinergic drugs
- Lowered bioavailability with simultaneous use of antacids and antisecretory drugs
- Metabolic pathway through CYP3A4
- Potential interaction with CYP3A4 inhibitors (e.g., azole antifungals, macrolide antibiotics)
- Influence on absorption of orally administered drugs
- No influence on blood levels of digoxin or paracetamol
Contraindications
- Hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage, mechanical obstruction, or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena in young children and adults
- Possible increase in plasma prolactin level leading to neuroendocrinological phenomena
- Rare allergic reactions like rash and urticaria
Pregnancy & Lactation
- Use only in first trimester of pregnancy if justified by therapeutic benefit
- Excretion in breast milk
- Not recommended during nursing unless expected benefits outweigh potential risk
Precautions & Warnings
- Increased risk of extra-pyramidal reactions in young children
- Caution in patients with hepatic impairment
Use in Special Populations
- Use with caution in infants due to incomplete development of blood-brain barrier
- Caution in patients with hepatic impairment
- Dosing frequency reduction in patients with severe renal insufficiency
Overdose Effects
- Symptoms include drowsiness, disorientation, and extrapyramidal reactions
- Administration of activated charcoal and close observation recommended
- Anticholinergic, antiparkinson drugs or antihistamines may help in controlling extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Used to treat nausea and vomiting
- Should be taken before meals as per the prescribed dose and duration
- May cause dizziness and sleepiness, caution when driving or doing activities requiring mental focus
- Avoid consuming alcohol while taking the tablet
- Inform the doctor in case of watery diarrhea, fever, or persistent stomach pain