Perion 10 mg (Tablet)

Unit Price: ৳ 2.30 (10 x 10: ৳ 230.00)
Strip Price: ৳ 23.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Globe pharmaceuticals ltd
Also available as
Perion 5 mg suspension

Title

  • Perion 10 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Perion 10 mg Tablet is a dopamine antagonist medication which is used to treat nausea and vomiting. It helps relieve dyspeptic symptom complex, acute nausea and vomiting, and Parkinson's disease-induced nausea and vomiting. It also aids in speeding barium transit in follow-through radiological studies.

Color Options

  • White

Dosage Form

  • Tablet
  • Suspension
  • Paediatric Drops
  • Suppositories

Dosage Instructions

  • Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily

Maximum Daily Dose

80 mg

Pharmacology

Dopamine antagonist that blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach. Gastroprokinetic action based on blocking effect of dopamine receptors influencing gastrointestinal motility.

Mechanism of Action

  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis and lower esophageal sphincter pressure

Interaction with Other Drugs

  • Anticholinergic drugs may antagonize the antidyspeptic effect of domperidone
  • Simultaneous administration with antacids and antisecretory drugs should be avoided
  • Metabolized through CYP3A4, so concomitant use of CYP3A4 inhibitors may result in increased plasma levels
  • Potential influence on absorption of concomitantly orally administered drugs

Contraindications

  • Known hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage, mechanical obstruction, perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Caution advised during the first trimester of pregnancy
  • Excreted in breast milk of lactating rats
  • Unknown potential harm to newborns
  • Effect on ability to drive and use machines: No effect on mental alertness

Precautions & Warnings

  • Use with caution in children due to risk of extra-pyramidal reactions
  • Use with caution in patients with hepatic impairment

Special Population Uses

  • Use in infants with caution under close medical supervision
  • Caution in patients with liver disorders
  • Dosage adjustment may be required in patients with severe renal insufficiency

Overdose Effects

  • Symptoms include drowsiness, disorientation, extrapyramidal reactions
  • Treatment may include activated charcoal and close observation

Therapeutic Class

  • Motility Stimulants
  • Motility stimulants/Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

Store below 30°C, Protected from light & moisture. Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Commonly Asked Questions

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