Gem 20 mg (Capsule (Enteric Coated))
Unit Price: ৳ 4.00 (60's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Omeprazole |
| Company | Millat pharmaceuticals ltd |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
- Inhibitor of gastric acid secretion
- Blocker of hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
- Onset of antisecretory effect within one hour
- Maximum effect within two hours
- Inhibition of secretion lasts up to 72 hours
Dosage
- Oral administration
- 20 mg once daily for 4 weeks in duodenal ulceration
- 8 weeks in gastric ulceration
- Maintenance dose for recurrent duodenal ulcer
- In prevention of relapse in duodenal ulcer
- 10-20 mg daily for long-term management of acid reflux disease
- 40 mg on the preceding evening for prophylaxis of acid aspiration
- IV Injection recommended for various conditions
Administration
- Direction for use of IV Injection for intravenous administration
- Direction for use of IV Infusion as an intravenous infusion over a period of 20-30 minutes or more
- Reconstituted solution should not be mixed with other drugs
Interaction
- Decreased intragastric acidity affecting the absorption of ketoconazole
- Metabolism through cytochrome P450 enzyme system affecting elimination of diazepam, phenytoin, and warfarin
- Monitoring and dose adjustment recommended with warfarin or phenytoin
- Increased plasma concentrations of Gem and clarithromycin during concomitant administration
- No evidence of interaction with phenacetin, theophylline, caffeine, etc.
Contraindications
- Patients with known hypersensitivity to Omeprazole
- Suspicion of gastric ulcer with possibility of malignancy
Side Effects
- Mild and reversible adverse reactions
- Skin rash, urticaria, and pruritus reported
- Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain reported
- Paraesthesia, dizziness, light headedness, and feeling faint associated with treatment
- Mental confusion, agitation, depression, and hallucinations reported predominantly in severely ill patients
- Arthritic and myalgic symptoms reported
- Increases in liver enzymes observed
Pregnancy & Lactation
- Omeprazole indicated to be used during pregnancy
- No information available on passage into breast milk or effects on neonate
- Breast-feeding should be discontinued if essential use of Omeprazole is considered
Precautions & Warnings
- Avoid concomitant use of clopidogrel and Gem
- PPI therapy associated with increased risk for osteoporosis-related fractures
- Atrophic gastritis noted occasionally in long-term treatment
- Concomitant use with methotrexate may lead to toxicities
Therapeutic Class
- Proton Pump Inhibitor
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children