HK 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (100's pack: ৳ 500.00)

Medicine Details

Category Details
Generic Omeprazole
Company Apollo pharmaceutical ltd

Indications

  • Treatment of gastric and duodenal ulcer
  • Treatment of NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Treatment of Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Omeprazole is an inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H/K ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually after discontinuation

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 20 mg once daily for NSAID-associated duodenal or gastric ulcer
  • 20 mg once daily for gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on the preceding evening for prophylaxis of acid aspiration
  • 60 mg once daily for Zollinger-Ellison syndrome
  • Paeditaric use in severe ulcerating reflux esophagitis

Administration

  • IV Injection should be given as a slow intravenous injection
  • IV Infusion should be given over a period of 20-30 minutes or more
  • IV solution should be used within 4 hours of reconstitution
  • IV infusion solution should be used within 12 hours when dissolved in saline and within 6 hours when dissolved in 5% Dextrose
  • Reconstituted solution should not be mixed with any other drug

Interaction

  • Decreased intragastric acidity may reduce the absorption of ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Can delay the elimination of diazepam, phenytoin, and warfarin
  • Monitoring of patients receiving warfarin or phenytoin is recommended
  • Plasma concentrations of HK and clarithromycin are increased during concomitant administration

Contraindications

  • Known hypersensitivity to omeprazole
  • When gastric ulcer is suspected, the possibility of malignancy should be excluded before treatment

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Diarrhoea and headache
  • Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dizziness, light headedness, and feeling faint
  • Arthritic and myalgic symptoms
  • Increases in liver enzymes

Pregnancy & Lactation

  • Omeprazole can be used during pregnancy
  • Breast-feeding should be discontinued if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and HK
  • PPI therapy may be associated with an increased risk for osteoporosis-related fractures
  • Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with HK

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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