Losek 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (30's pack: ৳ 210.00)

Medicine Details

Category Details
Generic Omeprazole
Company Bristol pharmaceuticals ltd
Also available as
Losek 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Dosage varies based on condition and severity
  • Oral and IV administration
  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Instructions for reconstitution of IV injection and infusion
  • Stability guidelines for reconstituted solution
  • No other route of administration

Interaction

  • Impact on absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting other drugs
  • Potential interaction with warfarin, phenytoin, and diazepam
  • Impact on plasma concentrations when co-administered with clarithromycin
  • No interaction with various drugs such as theophylline, caffeine, and antacids

Contraindications

  • Known hypersensitivity to Omeprazole
  • Need to exclude malignancy before treatment

Side Effects

  • Skin reactions including rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Gastrointestinal reactions like diarrhea and constipation
  • Headache, dizziness, and somnolence
  • Mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Potential liver-related adverse effects

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child
  • Use during pregnancy with caution
  • No information available for passage into breast milk
  • Discontinuation of breast-feeding if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Possible association with increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted in long-term treatment
  • Potential methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat

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