OM 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 3.02 (40's pack: ৳ 120.80)

Medicine Details

Category Details
Generic Omeprazole
Company Ambee pharmaceuticals ltd
Also available as
Om 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Oral administration for various conditions and durations
  • Initial doses for different ulcer types
  • Maintenance doses for recurrent conditions
  • Specific regimens for peptic ulcer disease and pediatric use
  • IV injection for prophylaxis and specific syndromes
  • Initial and recommended doses for Zollinger-Ellison Syndrome

Administration

  • Specific directions for IV injection and IV infusion
  • Reconstitution guidelines for IV injection and infusion
  • Usage duration of reconstituted solution
  • Precautions on mixing or co-administering with other drugs

Interaction

  • Effects on absorption of ketoconazole and other drugs during treatment
  • Metabolism in the liver through cytochrome P450
  • Potential delay in elimination of diazepam, phenytoin, and warfarin
  • Monitoring and dosage adjustments for patients receiving warfarin or phenytoin
  • Plasma concentration changes during concomitant administration
  • No evidence of interaction with certain drugs

Contraindications

  • Known hypersensitivity to omeprazole
  • Exclusion of malignancy before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme reported in isolated cases
  • Diarrhoea, headache, constipation, nausea/vomiting, and abdominal pain
  • Dry mouth, stomatitis, candidiasis, and paraesthesia reported
  • Dizziness, light headedness, and feeling faint associated with treatment
  • Resolvable mental confusion, agitation, depression, and hallucinations in severely ill patients
  • Arthritic and myalgic symptoms reported and resolved upon therapy cessation
  • Various isolated cases including blurred vision, taste disturbance, and gynaecomastia

Pregnancy & Lactation

  • No adverse effects on pregnancy or health of fetus/newborn child from prospective studies
  • Safe use during pregnancy
  • No available information on passage into breast milk or effects on the neonate
  • Breast-feeding discontinuation if essential use is considered
  • Safety and effectiveness not established in pediatric patients less than 18 years of age

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and omeprazole
  • Increased risk of osteoporosis-related fractures with proton pump inhibitor therapy
  • Atrophic gastritis occurrence with long-term treatment
  • Potential methotrexate toxicities with co-administration of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands