OM 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (20's pack: ৳ 120.00)

Medicine Details

Category Details
Generic Omeprazole
Company Ambee pharmaceuticals ltd
Also available as

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease treatment
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia treatment
  • Severe ulcerating reflux esophagitis treatment
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome treatment
  • Helicobacter pylori-induced peptic ulcer treatment

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily for severe or recurrent cases of gastric and duodenal ulcer
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia
  • 40 mg on preceding evening and 2-6 hours before surgery for prophylaxis of acid aspiration
  • Initially 60 mg once daily for Zollinger-Ellison syndrome
  • 20 mg twice daily for Helicobacter pylori eradication regimen in peptic ulcer disease
  • 10-40 mg once daily for severe ulcerating reflux esophagitis (paediatric use)

Administration

  • IV Injection for prophylaxis of acid aspiration, duodenal and gastric ulcer, and reflux oesophagitis
  • IV Infusion for severe ulcerating reflux esophagitis
  • Reconstitution and usage guidelines for IV injection and infusion

Interaction

  • Potential interactions with ketoconazole, diazepam, phenytoin, warfarin, clarithromycin, and digoxin

Contraindications

  • Known hypersensitivity to omeprazole
  • Suspicion of gastric ulcer with possibility of malignancy

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity and bullous eruption
  • Diarrhoea, headache, constipation, nausea/vomiting, flatulence, and abdominal pain
  • Dry mouth, stomatitis, and candidiasis
  • Paraesthesia, dizziness, and light headedness
  • Reversible mental confusion, agitation, and depression
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, and peripheral oedema
  • Increased sweating, gynaecomastia, and leucopenia
  • Hepatitis, interstitial nephritis, and hepatic failure
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • Safe for use during pregnancy
  • No information available on passage into breast milk or effects on neonate
  • Discontinuation of breastfeeding if essential use of omeprazole

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Occasional atrophic gastritis in long-term use
  • Possible methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands