OME 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.50 (6 x 10: ৳ 330.00)
Strip Price: ৳ 55.00

Medicine Details

Category Details
Generic Omeprazole
Company Somatec pharmaceuticals ltd
Also available as
Ome 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect occurs within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • 20 mg once daily for gastric and duodenal ulcer for 4-8 weeks
  • 10-20 mg daily for long-term management of acid reflux disease
  • 10-20 mg once daily for acid-related dyspepsia for 2-4 weeks
  • 40 mg on the preceding evening, then 40 mg 2-6 hours before surgery for prophylaxis of acid aspiration
  • Recommended doses and regimen for Zollinger-Ellison syndrome and Helicobacter pylori eradication regimen
  • Pediatric use: 10-20 mg once daily for children weighing 10-20 kg, 20-40 mg once daily for children weighing over 20 kg

Administration

  • IV Injection: Given slowly over a period of 5 minutes as prophylaxis of acid aspiration
  • IV Infusion: Given over a period of 20-30 minutes or more
  • Directions for reconstitution and usage of IV injection and infusion

Interaction

  • Decreased absorption of ketoconazole during OME treatment
  • Metabolism through cytochrome P450 affecting the elimination of diazepam, phenytoin, and warfarin
  • Monitoring recommended for patients receiving warfarin or phenytoin
  • Plasma concentrations of OME and clarithromycin are increased during concomitant administration

Contraindications

  • Known hypersensitivity to omeprazole
  • Must exclude possibility of malignancy before treatment in cases of suspected gastric ulcer

Side Effects

  • Mild and reversible adverse reactions reported
  • Skin rash, urticaria, pruritus, photosensitivity
  • Diarrhea, headache, constipation, nausea/vomiting, abdominal pain
  • Dry mouth, stomatitis, candidiasis, paraesthesia
  • Dizziness, light-headedness, somnolence, insomnia
  • Mental confusion, agitation, depression, hallucinations
  • Arthritic and myalgic symptoms
  • Blurred vision, taste disturbance, peripheral edema
  • Increases in liver enzymes

Pregnancy & Lactation

  • No adverse effects observed during pregnancy
  • No information available on passage into breast milk or effects on neonate
  • Discontinue breastfeeding if essential use of omeprazole

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and OME
  • Increased risk for osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted in gastric corpus biopsies from long-term OME usage
  • Concomitant use with methotrexate may lead to methotrexate toxicities

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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