Omel 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (10 x 10: ৳ 500.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Omeprazole
Company Medicon pharmaceuticals ltd
Also available as
Omel 40 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days

Dosage

  • Dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Helicobacter pylori eradication regimen in peptic ulcer disease
  • Paediatric use in severe ulcerating reflux esophagitis (Child>1 year)
  • IV injection dosage for various indications

Administration

  • Directions for use of IV Injection
  • Directions for use of IV Infusion
  • Use of freshly prepared solution
  • Reconstitution guidelines
  • Intravenous administration only
  • Slow intravenous injection
  • Intravenous infusion guidelines

Interaction

  • Decreased intragastric acidity affecting absorption of ketoconazole
  • Metabolism via cytochrome P450 impacting diazepam, phenytoin, and warfarin
  • Potential interaction with ketoconazole, clarithromycin, and antimicrobial agents
  • No evidence of interaction with phenacetin, theophylline, caffeine, propranolol, and others

Contraindications

  • Known hypersensitivity to Omeprazole
  • Potential malignancy in suspected cases of gastric ulcer

Side Effects

  • Skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, and erythema multiforme
  • Gastrointestinal reactions including diarrhea, nausea/vomiting, and flatulence
  • Neurological effects such as headache, dizziness, and somnolence
  • Reversible mental confusion, agitation, depression, and hallucinations
  • Arthritic and myalgic symptoms
  • Varied reports of other side effects like blurred vision, taste disturbance, and increased sweating

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • No adverse effects on pregnancy or on the health of the fetus/newborn child
  • No information available on passage into breast milk or effect on the neonate
  • Discontinuation of breastfeeding if essential use is considered

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Observational studies related to increased risk of osteoporosis-related fractures
  • Possibility of atrophic gastritis with long-term use
  • Potential of methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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