Ometid 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.27

Medicine Details

Category Details
Generic Omeprazole
Company Opsonin pharma ltd
Also available as
Ometid 20 mg capsule Ometid 40 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days after discontinuation

Dosage

  • Recommended dosage for benign gastric and duodenal ulcer
  • Dosage for NSAID-associated duodenal or gastric ulcer
  • Dosage for gastro-esophageal reflux disease
  • Dosage for long-term management of acid reflux disease
  • Dosage for acid-related dyspepsia
  • Dosage for prophylaxis of acid aspiration
  • Dosage for Zollinger-Ellison syndrome
  • Dosage for Helicobacter pylori eradication regimen in peptic ulcer disease
  • Pediatric use in severe ulcerating reflux esophagitis

Administration

  • Direction for use of IV Injection
  • Direction for use of IV Infusion
  • Instructions for intravenous administration
  • Instructions for intravenous infusion
  • Reconstitution guidelines for IV injection
  • Reconstitution guidelines for IV infusion
  • Stability and usage duration after reconstitution
  • Caution against co-administration in the same infusion set with any other drug

Interaction

  • Impact on absorption of ketoconazole
  • Metabolism through cytochrome P450
  • Possible delay in the elimination of diazepam, phenytoin, and warfarin
  • Plasma concentration changes during concomitant administration
  • No evidence of interaction with certain medications
  • Effect on the absorption of digoxin

Contraindications

  • Known hypersensitivity
  • Exclusion of malignancy before treatment initiation

Side Effects

  • Mild and reversible adverse reactions
  • Reported skin reactions such as rash, urticaria, and pruritus
  • Reports of photosensitivity, bullous eruption, and erythema multiforme
  • Gastrointestinal reactions including diarrhea, headache, constipation, and nausea/vomiting
  • Other reported reactions like dry mouth, stomatitis, paraesthesia, dizziness, and insomnia
  • Rarely reported cases of hepatic failure and increases in liver enzymes

Pregnancy & Lactation

  • Results from prospective epidemiological studies
  • No adverse effects on pregnancy or fetal health
  • Use during pregnancy
  • No information available on passage into breast milk
  • Recommendation to discontinue breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use with clopidogrel
  • Potential association with increased risk for osteoporosis-related fractures
  • Noted cases of atrophic gastritis in long-term treatment
  • Potential for methotrexate toxicities with concomitant use

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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