Omirex 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.50 (10 x 10: ৳ 550.00)
Strip Price: ৳ 55.00

Medicine Details

Category Details
Generic Omeprazole
Company Jayson pharmaceuticals ltd
Also available as
Omirex 40 mg capsule

Indications

  • Treatment of gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer treatment
  • Prophylaxis for patients with history of NSAID-associated duodenal and gastric ulcer
  • Treatment of gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Treatment of acid-related dyspepsia
  • Treatment of severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Treatment of Zollinger-Ellison syndrome
  • Treatment of Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Gradual return of secretory activity over 3 to 5 days upon discontinuation

Dosage

  • Oral administration for different conditions and durations
  • IV Injection for prophylaxis of acid aspiration
  • IV Injection for duodenal ulcer, gastric ulcer, or reflux oesophagitis
  • IV Injection for Zollinger-Ellison syndrome
  • Direction for use of IV Injection
  • Direction for use of IV Infusion

Administration

  • Intravenous administration only
  • Slow intravenous injection for IV Injection
  • Intravenous infusion over a period of 20-30 minutes or more for IV Infusion
  • Use only freshly prepared solution
  • Solution to be used within specific timeframes

Interaction

  • Potential interaction with ketoconazole
  • Metabolized in the liver through cytochrome P450
  • Potential interaction with diazepam, phenytoin, and warfarin
  • Monitoring recommended for patients receiving warfarin or phenytoin
  • Increased plasma concentrations during concomitant administration
  • No evidence of interaction with certain drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity
  • Possibility of malignancy should be excluded before treatment

Side Effects

  • Mild and reversible adverse reactions
  • Reported skin rash, urticaria, and pruritus
  • Photosensitivity, bullous eruption, erythema multiforme, angioedema, alopecia reported in isolated cases
  • Diarrhea, headache, constipation, nausea/vomiting, flatulence, abdominal pain reported
  • Dry mouth, stomatitis, candidiasis reported as isolated cases
  • Paraesthesia, dizziness, light headedness, feeling faint, somnolence, insomnia reported
  • Reversible mental confusion, agitation, depression, hallucinations reported
  • Arthritic and myalgic symptoms reported

Pregnancy & Lactation

  • No adverse effects indicated
  • Omeprazole can be used during pregnancy
  • No information available on passage into breast milk or effects on neonate

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Increased risk for osteoporosis-related fractures
  • Atrophic gastritis noted occasionally in long-term treatment
  • Potential methotrexate toxicities with concomitant use of PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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