Ompa 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (60's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Omeprazole
Company Seema pharmaceuticals ltd

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Actions on hydrogen-potassium-adenosine triphosphatase enzyme system
  • Onset of antisecretory effect within one hour
  • Maximum effect occurring within two hours
  • Inhibition of secretion lasting up to 72 hours

Dosage

  • 20 mg once daily for benign gastric and duodenal ulcer
  • 40 mg daily for severe or recurrent cases
  • 10-20 mg daily for NSAID-associated duodenal or gastric ulcer prophylaxis
  • 20 mg once daily for gastro-esophageal reflux disease
  • 40 mg once daily for 8 weeks in refractory cases of gastro-esophageal reflux disease
  • 10-20 mg daily for long-term management of acid reflux disease
  • 40 mg for prophylaxis of acid aspiration
  • 60 mg once daily for Zollinger-Ellison syndrome

Administration

  • IV injection for prophylaxis of acid aspiration and severe conditions
  • IV infusion for prolonged administration
  • Directions for use of IV injection and infusion

Interaction

  • Effect on the absorption of ketoconazole
  • Metabolism through cytochrome P450
  • Monitoring and dose adjustment for warfarin and phenytoin
  • No change in blood concentration of phenytoin and coagulation time with concomitant treatment
  • Plasma concentration changes with clarithromycin
  • No evidence of interaction with certain drugs
  • Effect on digoxin bioavailability

Contraindications

  • Hypersensitivity to omeprazole
  • Suspected gastric ulcer without excluding malignancy

Side Effects

  • Mild and reversible adverse reactions
  • Skin reactions like rash, urticaria, and pruritus
  • Photosensitivity and bullous eruption
  • Gastrointestinal reactions like diarrhea, constipation, and nausea/vomiting
  • Neurological symptoms like headache, dizziness, and paraesthesia

Pregnancy & Lactation

  • No adverse effects on pregnancy or fetus/newborn child reported
  • Use during pregnancy with no known harmful effects
  • No information on passage into breast milk
  • Discontinuation of breastfeeding if essential

Precautions & Warnings

  • Avoid concomitant use of clopidogrel
  • Possible risk of osteoporosis-related fractures with PPI therapy
  • Potential for atrophic gastritis with long-term use
  • Potential for methotrexate toxicities with concomitant use

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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